Böcker i Advances in Experimental Medicine and Biology-serien

The International Symposium on Hearing is a highly-prestigious, triennial event where world-class scientists present and discuss the most recent advances in the field of hearing research in animals and humans.

This book introduces the current concepts of molecular mechanisms in synaptic plasticity and provides a comprehensive overview of cutting-edge research technology used to investigate the molecular dynamics of the synapses.

This volume provides a representative survey of the current science of brain repair. It offers a broad introduction into molecular imaging, stem cell biology, cell therapy, animal models, central nervous system malignancies, stroke, and neurodegeneration.

Providing information on cystic fibrosis, this work is of interest to molecular biologists, physiologists, scientists working in pharmaceutical research and drug development, physicians and researchers in cystic fibrosis and related diseases.

The American Peptide Society (APS) provides a forum for advancing and promoting knowledge of the chemistry and biology of peptides.

This book covers current trends in the investigation of GI microbiota. It examines the relationship between the microbiota and the immune system from a variety of angles.

The aim of this book is to present a unique compilation of lectures given by international speakers at the Hammersmith Hospital during the recent Meetings in Hepato-Pancreato-Biliary and Transplantation.

This book will describe the nuclear encoded genes and their expressed proteins of mitochondrial oxidative phosphorylation. For complex IV (cytochrome c oxidase) some of these subunits occur in tissue-specific (subunits IV, VIa, VIb, VIIa, VIII), developmental-specific (subunits IV, VIa, and VIIa) as well as species-specific isoforms.

Cell surface molecules are critically important in regulating cell structure and function.

The book presents current progress in clinical practice and research, particularly involving pulmonary diseases. Chapters tackle a variety of topics including a search for potential biomarkers of lung tumors, sleep disordered breathing, neurogenic lung dysfunction, community acquired and nosocomial respiratory infections developing in the chronically ill, mechanisms of hypoxia sensing, and the reasons for frequent visits to primary care facilities causing an ever increasing costs for caregivers and society. Identifying molecular markers expressed in tumors, rather than histological stratification of cancer type, forms a rapidly evolving basis of precision medicine, with the hope of a future development of targeted treatment. Creative ideas drive basic research that spurs innovations that, in turn, when translated into clinical applications, lay the foundation of breakthroughs, hopefully leading to increased longevity and better quality of life. This book is intended for healthcare professionals, particularly pulmonologists, primary care physicians, and other specialists involved in the management of patients.

This book provides a comprehensive view of metabolomics, from the basic concepts, through sample preparation and analytical methodologies, to data interpretation and applications in medicine.

Pulmonary diseases are the major cause of human morbidity, taxing the health care system due to disease prevalence, chronicity, and social and fiscal costs. Inflammation also is an essential component of non-communicable lung diseases, including asthma and respiratory allergies, and smoking-related or granulomatous diseases.

This book presents a range of research and clinical contributions, including observational studies, practical treatment examples, diagnostic test assessment, biomarkers, and systematic reviews.

This book aims to introduce the latest research in gut microbiota by systematically summarizing how it modulates the pathogenesis of organ injury including alimentary tract injury, liver injury, lung injury, brain injury, renal injury, heart and vascular injury, endocrine disorders, immune responses and multiple organ dysfunction syndrome (MODS) during sepsis. Gut microbiota which is recognized as a new ¿organ¿ in the body has been demonstrated to be able to regulate the homeostasis of many organs. The key role played by gut microbiota is the hotspot in biomedical research nowadays. This book provides a state-of-the-art report on recent discoveries regarding the novel insight into the mechanisms of human diseases progression. It will also offer the overall picture of the pathophysiologic roles of gut microbiota. This book is helpful for graduate students and professional researchers to get the knowledge of frontiers in both gut microbiota and organ injury.

This comprehensive volume explores human genetic engineering its pre-clinical and clinical applications, current developments, and as treatment for hereditary diseases. It presents and evaluates the most recent advances in the understanding of mammalian host DNA repair mechanisms, such as double-strand break induced gene targeting and mutagenesis, the development of zinc-finger nucleases, genome editing for neuromuscular diseases, phase integrases, triplex forming oligonucleotides and peptide nucleic acids, aptamer-guided gene targeting, AAV gene editing via DSB repair, engineered nucleases and trinucleotide repeat diseases, and creation of HIV-resistant cells. The expertly authored chapters contextualize current developments within the history of genome editing while also discussing the current and potential safety concerns of this rapidly growing field.Genome Editing: The Next Step in Gene Therapy, the latest volume in the American Society of Gene and Cell Therapy series, deftly illuminates the potential of genetic engineering technology to eradicate today¿s deadliest and most prolific diseases. It is ideal reading for clinicians and researchers in genetics and immunology.

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions.This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature's longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the third volume of a continuing series.

The chapters of this book deal with the preventable drivers of poor respiratory health, the role of health information technology, the improvement in health care delivery and the integration of respiratory health and behavioral health services.

The purpose of this book is to provide an up to date review of the nature and consequences of epigenetic changes in cancer. These changes include alterations in global and promoter specific DNA methylation, activating and repressive histone modifications, and changes in higher order chromatin structures.

This edited reflects the current state of knowledge about the role of microRNAs in the formation and progression of solid tumours. Bioinformaticians and modellers are provided with a general perspective on microRNA biology in cancer, and the state-of-the-art in computational microRNA biology.

Consumer understanding of the concept of early nutrition programming and the extent to which early nutrition programming is taken into account in infant feeding policies are also discussed.

This book discusses the different regulatory pathways for gene therapy (GT) and cell therapy (CT) medicinal products implemented by national and international bodies throughout the world (e.g.

This ground-breaking book brings together researchers from a wide range of disciplines to discuss the control and coordination of processes involved in perceptually guided actions.

This book is a blend of medical research and clinical practice. Hopefully, it will be a source of information on interdisciplinary medical research advancements, addressing the needs of medical professionals, from scientists to clinicians and allied health professionals.

This book series focuses on current progress in the broad field of medical microbiology, and covers both basic and applied topics related to the study of microbes, their interactions with human and animals, and emerging issues relevant for public health.

Due to continuous technical developments and new insights into the high complexity of neurological diseases, there is an increasing need for the application of proteomic technologies which can yield potential biomarker readouts for improved clinical management as well as for the development of new drugs by struggling pharmaceutical companies.

Pulmonary disorders significantly contribute to the current level of disease burden. This book highlights the issues involved with diagnosing and managing various pulmonary conditions such as chronic obstructive pulmonary disorders, respiratory tract infections, including those developing as a sequel of antibiotic treatment, and others.