Böcker i Chromatographic Science Series-serien

This book gives the pertinent information on the high pressure liquid chromatography (HPLC) analyses of all the compounds of interest in nucleic acid metabolism. It aids chromatographers, biochemists, biomedical researchers, and chemists by giving information on applications of HPLC technique.

This book discusses flow perturbation method, namely, the stopped-flow technique and the reversed-flow technique. It is directed to those who need an accurate method for the determination of a certain physicochemical quantity and to researchers working on the development of gas chromatography.

This book focuses on a relatively new approach to chemical analysis in general, and to separation science in particular. It is the first book to systemically cover the theoretical background, techniques, instrumentation, and practical applications of planar chromatography ¿ mass spectrometry as a hyphenated tool of analytical chemistry. It also examines the high and as-yet unexploited potential of planar chromatography¿mass spectrometry for analytical use in scientific investigations and promotes its expanded use in academia and industry.

This book serves as a comprehensive source of information and training on the state-of-the-art pesticide residues methods performed with aid of HPLC and aids the readers in avoiding the many pitfalls that are possible during work with the HPLC mode

Reviews the use of surfactant solutions at or above the critical micelle concentration as mobile phases in liquid chromatography. This title employs a computer-assisted optimization methodology and integrates micellar liquid chromatography (MLC) with other chromatographic and electrophoretic techniques using surfactants.

This book provides a comprehensive source of knowledge of new sorbent materials, presenting fundamental principles for their syntheses, and adsorption properties. It presents advanced techniques employed to create specialized sorbents with a wide range of functions, which can be used to enhance the separation and/or purification of useful bioactive compounds, heavy metals, dyes, and more. It discusses original results compared with the most recent developments in the field of separation processes, covering specialized sorbents such as monolith cryogels, composite hydrogels, metal impregnated ion exchangers, and molecularly imprinted polymers.

An up-to-date, complete reference, this book covers the most important methods in pharmaceutical applications of TLC, namely, analysis of bulk drug material and pharmaceutical formulations, degradation studies, analysis of biological samples, optimization of the separation of drug classes, and lipophilicity estimation. Part I is devoted to general topics related to TLC in the context of drug analysis. Part II provides an in-depth overview of a wide range of TLC applications for separation and analysis of particular drug groups.

Explains how preparative layer chromatography is used for separating large quantities of mixtures containing a variety of important compounds. This work offers a review of preparative layer chromatography (PLC) applications and adaptable working procedures for microseparations involving organic, inorganic, and organometallic compounds.

Introduces scientists of various disciplines to the chromatographic process and how it functions. This title covers the basic principles of chromatographic separation and specific chromatographic procedures, including gas, liquid and thin-layer chromatography. It is suitable for analytical chemists and graduate students in analytical chemistry.

Describes the developments in the scaling-up and application of chromatographic operations and demonstrates that production-scale chromatography is a powerful and invaluable separation process. This book covers the various important process designs and reveals actual, immediately applicable techniques.

Presents practical information on the application of capillary electrophoresis (CE) to protein analysis, with an emphasis on developing and optimizing CE techniques in the laboratory. This title includes separation methods bases on mass, charge, isoelectric point, molecular sieving, and affinity interactions.

This volume is the first book to give a complete description of the techniques, materials, and instrumentation of column HPLC and its application to essentially all primary and secondary plant metabolites. It describes the techniques and instrumentation of HPLC analysis, such as HPLC/nuclear magnetic resonance spectrometry, HPLC with photodiode array detection, and HPLC chiral analysis. It explores the application of HPLC to primary and secondary plant metabolites and discusses how HPLC is used for analyzing herbal drugs and dietary supplements.

This book provides a detailed description of technical elements of a microbore column liquid chromatograph suitable for use in trace analysis. It presents examples of analyses, especially from the spheres of biochemistry, pharmacology, and environmental analytical chemistry.

Considers three fundamental aspects of molecular interactions important in chromatography, taking care not to duplicate information readily available in other references. Surveys the basic factors involved in complex formation, which governs the retention mechanism and selectivity in either donor or

This book discusses flow perturbation method, namely, the stopped-flow technique and the reversed-flow technique. It is directed to those who need an accurate method for the determination of a certain physicochemical quantity and to researchers working on the development of gas chromatography.

This important, new reference provides the first , up-to-date, and comprehensive treatmentof the various liquid chromatography (LC) instrumentation for Therapeutic DrugMonitoring (TDM) and toxicology drug assays and reviews the clinical pharmacologyof major classes of drugs and their LC analyses

Covering advancements in separation technique, this book presents concepts including monolithic columns, bonded stationary phases, micro-HPLC, two-dimensional comprehensive liquid chromatography, and capillary electromigration techniques. It covers areas of HPLC application, including chiral pharmaceutical, food, and forensic analysis.

This book describes new gel permeation chromatography/liquid chromatography applications and techniques that will provide polymer scientists and practitioners with insight into the development of new polymers and plastics and improvement of existing materials.

This book describes the various aspects of microbore column chromatography. It provides readers with an in-depth understanding of the supercritical fluid chromatography and microbore high-performance liquid chromatography.

This book informs the reader about the practical methods, possibilities, and limits of template chromatography. It shows the various techniques for immobilization of nucleic acids fragments, polynucleotides, and nucleic acids by which the desired separation of materials can be achieved.

This book summarizes all the important aspects of multidimensional separations, providing information on gas, liquid and thin-layer chromatography, as well as the techniques and applications of supercritical fluid chromatography in the multidimensional mode.

This book documents the principles of operation, the advantages and drawbacks, and the potential future of currently available liquid chromatographic detectors. In offering a snapshot of the current technology, it provides clear explanations and possible new horizons for both beginners and experts.

This book covers a range of topics of interest to those involved in the fractionation and characterization of polymeric substances. It deals with problems that are encountered in modern gel permeation chromatography with dual detection when calculating average molecular weights.

Shows how to choose the most effective techniques for assessing the toxicity of chemicals in both food and the environment. This title examines a range of volatile compounds from toxic aldehydes and pesticides to micotoxins and dioxins.

Chirality plays a major role in biological processes and the enantiomers of a bioactive molecule often possess different biological effects. Accurate assessment is critical as isomeric impurities may have unwanted toxicological, pharmacological, or other effects. Separation techniques remain the method of choice for this area of drug research but there is a great deal of trial and error in choosing a particular column for a chiral separation. This book gives a rationale for choosing a stationary phase that is based on the relationship that exists between the analytes and the chiral stationary phases. The text provides examples to underline the separation mechanism.

Focuses on the various aspects of the microfluidic lab-on-a-chip technologies and offers an overview of the available technology, its limitations and its breakthroughs over the years. This work emphasizes analytical applications of microfluidic technology and offers coverage of micromachining methods, microfluidic operations and injection methods.

Active chemical compounds in the pharmaceutical products existing on the market need to be characterized with respect to their properties, or compared to other similar products, already available for direct use. The book describes sampling methodologies, preparation methods, separation possibilities and assay of these compounds at low concentration levels in complex matrixes. The steps covered are taken before launching a new pharmaceutical product on the market for estimating its pharmacokinetic behavior, or before authorizing for marketing of a generic pharmaceutical product.

Explains to chromatographers that gas-liquid chromatography, a development of gas chromatography, is itself just a limited case of gas-liquid-solid chromatography.

This thoughtfully constructed edited reference presents the main chromatographic methodologies and strategies used to discover and analyze novel designer drugs contained in diverse biological materials.