Böcker i Computational Biology-serien

The three-dimensional structure and function of molecules present many challenges and opportunities for developing an understanding of biological systems. With the increasing availability of molecular structures and the advancing accuracy of structure predictions and molecular simulations, the space for algorithmic advancement on many analytical and predictive problems is both broad and deep. To support this field, a rich set of methods and algorithms are available, addressing a variety of important problems such as protein-protein interactions, the effect of mutations on protein structure and function, and protein structure determination. Despite recent advancements in the field, in particular in protein folding with the development of AlphaFold, many problems still remain unsolved.In this book we focus on a number of topics in Structural Bioinformatics: Cryo-EM structural detection, protein conformational exploration, elucidation of molecular binding surface using geometry, the effect of mutations, insertions and deletions on protein structural stability, and protein-ligand binding.

To date, processing of high-throughput Mass Spectrometry (MS) data is accomplished using serial algorithms. Developing new methods to process MS data is an active area of research but there is no single strategy that focuses on scalability of MS based methods.  Mass spectrometry is a diverse and versatile technology for high-throughput functional characterization of proteins, small molecules and metabolites in complex biological mixtures. In the recent years the technology has rapidly evolved and is now capable of generating increasingly large (multiple tera-bytes per experiment) and complex (multiple species/microbiome/high-dimensional) data sets. This rapid advance in MS instrumentation  must  be matched by equally fast and rapid evolution of scalable methods developed for analysis of these complex data sets. Ideally, the new methods should leverage the rich heterogeneous computational resources available in a ubiquitous fashion in the form of  multicore,  manycore,  CPU-GPU, CPU-FPGA, and IntelPhi architectures.  The absence of these high-performance computing algorithms now hinders scientific advancements for mass spectrometry research. In this book we illustrate the need for high-performance computing algorithms for MS based proteomics, and proteogenomics and showcase our progress in developing these high-performance algorithms.

Navigating safely through a wealth of genome, protein and metabolite information, as well as a host of information processing tools, without getting lost is crucial for successful research in - and teaching of - molecular biology.This concise, easy-to-follow textbook/guide serves as a valuable introduction to contemporary cell biology for readers and offers insight into the key research directions in the field. It begins with an overview of existing tools for finding, designing and investigating metabolic, genetic, signalling and other network databases. This practical guide then introduces Cell Illustrator®, a software tool for biological pathway modelling and simulation, developed by the authors. In-depth discussion reveals how this tool can be used for creating, analyzing and simulating biological models, thereby explicating and testing current understanding of basic biological processes. Readers do not require prior knowledge of differential equations or programming.Features:¿ Provides many helpful learning aids, such as detailed examples throughout, and exercises and solutions¿ Designed and structured to be part of a semester-long course¿ Discusses the computational functionalities required for Systems Biology¿ Addresses practical issues surrounding software tools¿ Introduces the current big bio-databases such as TRANSPATH® by Biobase, and explains why and how they can be used to develop and support systems biology research¿ Explains important pathway databases and software tools, together with their related concepts¿ Guides the reader to model pathways in a step-by-step and clear manner>Written for undergraduates, this reader-friendly introduction to the field of Systems Biologyoffers insight and teaches sound expertise in the subject. It will also prove valuable to graduate students and professionals wishing to develop and support their systems-biology research.

This is a book about software engineering, bioinformatics, the C++ programming language and the SeqAn library.

This book explores association mapping in experimental populations and genome-wide association studies (GWAS), emphasizing methods based on modifications of Bayesian information criterion, for handling testing problems in large-scale scans for trait loci.

Specifically, it discusses an array of techniques related to biological network clustering, network summarization, and differential network analysis which enable readers to uncover the functional and topological organization hidden in a large biological network.

This unique textbook/reference presents unified coverage of bioinformatics topics relating to both biological sequences and biological networks, providing an in-depth analysis of cutting-edge distributed algorithms, as well as of relevant sequential algorithms.

This book describes core processes of replication, mutation, neutral evolution and natural selection, genome evolution in prokaryotes, eukaryotes, vertebrates and humans, genome sequencing amd more, offering worked-out examples and extensive appendices.

The field of bioinformatics continues to develop energetically. This second edition covers new findings using the formula of the original text. It is self-contained, bringing together the multiple disciplines necessary for a profound grasp of the field.

The advances of live cell video imaging and high-throughput technologies for functional and chemical genomics provide unprecedented opportunities to understand how biological processes work in subcellularand multicellular systems. The interdisciplinary research field of Video Bioinformatics is defined by BirBhanu as the automated processing, analysis, understanding, data mining, visualization, query-basedretrieval/storage of biological spatiotemporal events/data and knowledge extracted from dynamic imagesand microscopic videos. Video bioinformatics attempts to provide a deeper understanding of continuousand dynamic life processes.Genome sequences alone lack spatial and temporal information, and video imaging of specific moleculesand their spatiotemporal interactions, using a range of imaging methods, are essential to understandhow genomes create cells, how cells constitute organisms, and how errant cells cause disease. The bookexamines interdisciplinary research issues and challenges with examples that deal with organismal dynamics,intercellular and tissue dynamics, intracellular dynamics, protein movement, cell signaling and softwareand databases for video bioinformatics.Topics and Features. Covers a set of biological problems, their significance, live-imaging experiments, theory andcomputational methods, quantifiable experimental results and discussion of results.. Provides automated methods for analyzing mild traumatic brain injury over time, identifying injurydynamics after neonatal hypoxia-ischemia and visualizing cortical tissue changes during seizureactivity as examples of organismal dynamics. Describes techniques for quantifying the dynamics of human embryonic stem cells with examplesof cell detection/segmentation, spreading and other dynamic behaviors which are important forcharacterizing stem cell health. Examines and quantifies dynamic processes in plant and fungal systems such as cell trafficking,growth of pollen tubes in model systems such as Neurospora Crassa and Arabidopsis. Discusses the dynamics of intracellular molecules for DNA repair and the regulation of cofilintransport using video analysis. Discusses software, system and database aspects of video bioinformatics by providing examples of5D cell tracking by FARSIGHT open source toolkit, a survey on available databases and software,biological processes for non-verbal communications and identification and retrieval of moth imagesThis unique text will be of great interest to researchers and graduate students of Electrical Engineering,Computer Science, Bioengineering, Cell Biology, Toxicology, Genetics, Genomics, Bioinformatics, ComputerVision and Pattern Recognition, Medical Image Analysis, and Cell Molecular and Developmental Biology.The large number of example applications will also appeal to application scientists and engineers.Dr. Bir Bhanu is Distinguished Professor of Electrical & C omputer Engineering, Interim Chair of theDepartment of Bioengineering, Cooperative Professor of Computer Science & Engineering, and MechanicalEngineering and the Director of the Center for Research in Intelligent Systems, at the University of California,Riverside, California, USA.Dr. Prue Talbot is Professor of Cell Biology & Neuroscience and Director of the Stem Cell Center and Core atthe University of California Riverside, California, USA.

This interpretation enables a remarkably unified view of the entire field of biology to be taken and hence offers an excellent entry point into the life sciences for those for whom biology is unfamiliar.