Böcker i Experientia Supplementum-serien

This book provides an up-to-date overview on the biology of microsporidia, focusing on areas where significant progress has been made in recent years. In particular, our understanding of the evolutionary position and the role of genome reduction in the biology of these enigmatic intracellular pathogens is discussed. This book also offers important updates on the mechanisms used by these organisms to modify the host cell biology of mammals, insects, nematodes, and aquatic animals, as well as the mechanisms controlling infection and host specificity. Readers gain a detailed overview of the structure and function of the polar tube, the unique invasion apparatus of microsporidia, as well as the physics and dynamics of spore firing. Particular attention is given to chronic infections in mammals caused by microsporidia, as well as common immune responses.Written by an international team of authors representing the main research groups working on microsporidian biology, this book is a valuable resource for health management professionals, experienced microbiologists, and early career scientist alike who want to learn more about these fascinating parasites. The ideas and latest finding covered in this book contribute to UN Sustainable Development Goal 3: Good Health and Well-Being.  Chapter "e;Impact of Genome Reduction in Microsporidia"e; is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

This book provides a comprehensive overview of the genetic basis underlying endocrine diseases. Several endocrine diseases have a genetic background, and contemporary research in the field plays a crucial role in the clinical care of endocrine diseases.

This book focuses on host-pathogen interactions at the metabolic level. It explores the metabolic requirements of the infectious agents, the microbial metabolic pathways that are dedicated to circumvent host immune mechanisms as well as the molecular mechanisms by which pathogens hijack host cell metabolism for their own benefit.

This project will show the context where inflammasomes are being studied and the molecular implications in the medical and clinical contexts. Other important topic of the inflammasomes will be the development of pharmacological inhibitors in order to improve new clinical applications.

This work was compiled to serve as a convenient source that covers a number of techniques (and details of their use) in the rather large field of nanomedicine, with special attention paid to gene delivery.

AMPK has emerged as an important integrator of signals that control energy balance through the regulation of multiple biochemical pathways in eukaryotes. The contributions are written by leading experts in the field and give an extensive overview of the current knowledge of AMPK biology and the role of AMPK in health and disease.

During the period the sponges described herein were which were used only sporadically in the past and were collected (1963-7), the author was a Research Associate regarded as of marginal value until two decades ago, at the Department of Geology, University of Illinois, paleontology and embryology, are now receiving great participating in a research project on carbonate attention. They have already brought drastic revisions to sediments of the Bimini area, directed by Prof. William systematics, with regard to redefinition and classification W. Hay (Department of Geology, University of Illinois. of higher taxa. Other approaches have recently emerged utilizing biochemistry, histology, cytology, autecology, now at the Rosenstiel School of Marine and Atmospheric and zoogeography, and these promise significant ad­ Science, University of Miami) and supported by the National Science Foundation. The objective of this pro­ vance in the delimitation and classification oflower taxa. ject was a study of the relationship between the carbo­ The rapidly changing state of sponge taxonomy is reflect­ nate sediments of the Bimini area and the benthonic ed in the paucity of definitive (i. e. widely accepted) revisions of genera and families. The lack of stability and fauna and flora, especially with regard to skeletal ele­ ments contributed to the sediment.

Many arthropods use celestial (skylight) and terrestrial (magnetic) compass cues for orientation, and some of them were shown to develop, through experience, oriented behaviours based on a variety of innate, hard-wired orientation mechanisms.

Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer.

As a consequence, researchers and project managers in the pharmaceutical industry should have a solid knowledge of the more important methods available to drug discovery, because it is the rapidly and intelligently combined use of these which will determine the success or failure of preclinical projects.

Galanin is a neuropeptide found both in the central and peripheral nervous system. The studies reviewed in this volume give a fairly complete overview of the spectrum of the biological actions and functions of galanin and its receptors and on possible therapeutic applications in a number of pathological conditions.

It is no longer time-consuming analysis of unknown products, but rather selective identifications of individual forms, modifications and processings, and overall analysis of global protein outputs from cells and tissues in health and disease.

The present book is the ideal complement to the practitioner's manual Techniques in Molecular Systematics and Evolution, recently published by the same editors in the Birkhauser MTBM book series.The first part of this book deals with important applications of evolutionary and systematic analysis at different taxonomic levels.

Aims to understand, from a evolutionary perspective, the impact of stress on biological systems. This work discusses the role of stress in evolutionary change, from stress induced mutations and selection to speciation and evolution at the geological time scale.

The recognition of the role of NPY in stimulation of food intake has already resulted in discovery of potent and selective NPY receptor Y-5 antagonists which are in clinical development for obesity while NPY Y1 receptors are targeted for cardiovascular indications.

The present book is the ideal complement to the practitioner's manual Techniques in Molecular Systematics and Evolution, recently published by the same editors in the Birkhauser MTBM book series.The first part of this book deals with important applications of evolutionary and systematic analysis at different taxonomic levels.