Catalyst/Polymerization: Model Silica Supported Olefin Polymerization Catalysts (J.P. Blitz). Statistical Propagation Models for ZieglerNatta Polymerization (H.N. Cheng). Supported Catalysts in Stirred Bed Gas Phase Reactors (K.D. Hungenberg, M. Kersting). Functionalization: Functional Polyolefins Prepared by Borane Research (T.C. Chung). Synthesis of PolyolefinPMMA Graft Copolymers (T.C. Chung et al.). Supported Lewis Acid Catalysts Based on Polyolefin Thermoplastics (T.C. Chung, A. Kumar). Characterization: Structure, Crystallization, and Melting of Linear, Branched, and Copolymerized Polyethylenes as Revealed by Fractionation Methods and DSC (V.B.F. Mathot). Development of High Performance TREF for Polyolefin Analysis (L. Wild, C. Blatz). NMR Analysis of Multicomponent Polyolefins (H.N. Chang). Polyolefin Blends and Composites: PolyethyleneCopolymer Blends (B. Crist, J. Rhee). Interphase Design in Cellulose Fiber/Polypropylene Composites (P. Gatenholm, J.M. Felix). 7 additional articles. Index.
History of Weak Interactions; T.D. Lee. Physics at LEP; L. Foà. Electroweak Precision Tests; R. Barbieri. Chiral Perturbation Theory; G. Ecker. CP- and T-Violations in the Standard Model; J.M. Gérard. Heavy Flavor Physics; K. Berkelman. Physics at HERA; G. Wolf. Physics with Hadron Colliders; M.J. Shochet. Neutrino Physics; B.C. Barish. Inflation after COBE; M.S. Turner. Oblique Electroweak Parameters and Additional Fermion Generators; G. Bhattacharyya. Electroweak Symmetry Breaking from the Top; N. Evans. Higgs Mass Limits from Electroweak Baryogenesis; S. Myint. Carbon 60; T.D. Lee. Index.
Overview: Recombination of Atomic Ions; D. Bates. Applications of Recombination; H. Summers, W.J. Dickson. Theoretical Aspects of Recombination: Dielectronic Recombination Theory; K.J. LaGuttuta. Beyond the Standard Computational Method for Dielectronic Recombination of Atomic Ions; M.S. Pindzola, et al. Experimental Measurements 1. ElectronIon Recombination: Early Measurements of Dielectronic Recombination; P.F. Dittner, S. Datz. Dielectronic Recombination Measurements Using the Electron Beam Ion Trap; D.A. Knapp. Laser-Stimulated Radiative Recombination; A. Wolf. Experimental Measurements 2. Ion-Atom Recombination: Resonant Transfer Excitation Associated with Single X-Ray Emission; J.A. Tanis. Dielectronic Excitation and Recombination in Crystal Channels; S. Datz, et al. Resonant Transfer and Excitation in Ion Channelling; M.W. Clark, et al. 17 additional articles. Index.
Introduction: From Fluid Particles to Physical Particles; M. Mareschal, B.L. Holian. Non-Equilibrium Molecular Dynamics: Theoretical Foundation and Rheological Application of NonEquilibrium Molecular Dynamics; G. Ciccotti, et al. Lattice Gases: Lattice Boltzmann Simulation of High Reynolds Number Fluid Flow in Two Dimensions; G. McNamara, B.J. Alder. Other Simulation Methods: A Contemporary Implementation of the Direct Simulation Monte Carlo Method; G.A. Bird. Chaos, Turbulence, and Irreversibility: Lyapunov Exponents and Bulk Transport Coefficients; D. Evans, et al. Related Topics: Statistical Fracture Mechanics; A. Chudnovsky, B. Kunin. Recollections: The Long Time Tail Story; B.J. Adler. 22 additional articles. Index.
Introduction; L.C. Chen, et al. Epidemiolgy and Policy: AIDS and Reproductive Health; K. LaGuardia. Policy and Legal Aspects of AIDS Interventions; H. Fineberg. Risk Factors in Transmission: Factors Affecting Female-to-Male Transmission of HIV1; F.A. Plummer, et al. Interrelationships Between HIV Infection and Other STDs; J. Wasserheit. Contraception, Family Planning, and HIV; D. Hunter, J.K.G. Mati. Perinatal Transmission: Mother to Fetus/Infant Transmission of HIV1; O. Meirik. HIV Perinatal Transmission and Reproductive Health; P. Kanki, et al. Methods for Decreasing HIV Transmission to Infants; S.J. Heymann. Interventions: An Overview of AIDS Interventions in High-Risk Groups; P. Lamptey. Intervention Research Needs for AIDS Prevention Among Commercial Sex Workers and Their Clients; B. de Zalduondo, et al. 7 additional articles. Index.
Invited Papers.- Theory of Electron Collisions in Partially Ionized Gases.- Electron Collisions with Molecules.- Electron Transport in Partially Ionized Gases.- Non Equilibrium Plasma Kinetics.- Modeling High Pressure Electric Discharges: Applications to Excimer Lasers.- Energy Transfer in Atom/Molecule Collisions with Molecules and Surfaces.- Reactivity Calculations for Elementary Atom-Diatom Processes and Applications to Non-Equilibrium Systems.- Excimer Lasers: Status and Perspectives.- Fundamental Properties of RF Glow Discharges: An Approach Based on Self-Consistent Numerical Models.- Theory of High-Frequency Discharges.- Volume Production of Hydrogen Negative Ions.- Laser Diagnostics of a Hydrogen Discharge.- Hydrogen-Surface Interactions.- Plasma Assisted Thin Film Production WC, a-C: H and Diamond Films.- Electric Discharge Lamps.- Contributed Papers.- Inelastic Scattering of Electrons From H2 Molecule and First-Born Approximation: Role Of Correlation.- Electron-Molecule Collision Cross Sections for Etching Gases.- Electron Collisions in Gas Switches.- Theory of e- -Diatom Scattering at Low Energies.- A Parameter-Free Theoretical Model for Low-Energy Electron Scattering from Polyatomic Molecules.- Electron Collision Cross-Sections Determined from Beam and Swarm Data by Boltzmann Analysis.- Electron Collision Cross Sections Involving Excited States.- Electron Collision Cross Sections Involving Excited States.- New Theoretical Approaches for Studying Electron Collisions with Small Molecules.- Ion-Neutral Reactions.- Energy Pooling Collisions: A Step Towards Ionization.- Potential Energy Curves of Open Shell Systems (Excimers) from Molecular Beam Scattering.- Molecular Beam Measurements of Ionization Cross Sections Relevant to Thermal Plasmas and Excimer Laser Systems.- The Silent Discharge and Its Application to Ozone and Excimer Formation.- Non Equilibrium Excimer Laser Kinetics.- Study of A Photoswitched Discharge for Excimer Laser.- A Self-Consistent Monte Carlo Modeling of RF Non-Equilibrium Plasma.- Charged Particles Dynamics in Electropositive Glow Discharges Probed by Optical Diagnostics.- Problems in the Experimental Determination of Electron Energy Distribution Function in RF Discharges.- Spectroscopic Diagnostics in the Cathode Fall and Negative Glow of a Nitrogen Glow Discharge.- Electron Kinetics in RF Discharges.- A Radiofrequency Trap for Tests on Production and Excitation of Ions.- Gas-Phase and Gas-Surface Interactions of Vibrationally Excited Hydrogen Molecules.- Translational Energy Distribution Functions of H+ and H in H2 Volume Discharges.- Numerical Simulation on Tandem Negative Ion Source.- Atomic and Molecular Surface and Volume Processes in the Analysis of Negative Hydrogen Discharges.- Interpretation and Analysis of the H2 Vibrational Distribution in a Hydrogen Discharge.- Electron Energy Distribution Functions in Magnetic Multipole Plasmas.- Effects Due to Negative Ions and Particles in Plasmas.- Electron and Vibrational Kinetics in Molecular Discharges.- Laser Diagnostic of Radio-Frequency Oxygen Plasma.- Spectroscopy and Kinetics of an Oxygen Glow Discharge.- Simulation Work in Noble Gas Radiation Detectors.- A Description of The Non-Equilibrium Behavior of Electrons in Matter: Macro-Kinetics.- Thermalization and Transport of Sputtered Particles in Glow Discharges.- The Free Electron Laser: A Simple Quantum Picture.- Electron and Photon Collisions in Strong Laser Fields.- Resonant Photopumping of Lithiumlike Ions in Laser-Produced Plasmas.- Ionization and Deionization of Electron Beam Disturbed Air.- Re-Entry Problems.- Diagnostics of Atomic Species Near the Electrodes of a Fluorescent Lamp.- Excited State Diagnostics in High Pressure Arc Lamps.- Participants
Protein Structures: The Cooperative Substructure of Protein Molecules; Y. Bai, S.W. Englander. Protein Folding: Approaches to the Determination of More Accurate Crossrelaxation Rates and the Effects of Improved Distance Constraints on Protein Solution Structures; G.C. Hoogstraten, J.L. Markley. Protein Interactions: How Conventional Antigens and Superantigens Interact with the Human MHC Class II Molecule HLADR1; T. Jardetzky. Nucleic Acids and Nucleic Acid-Protein Interactions: Stimulating the Dynamics of the DNA Double Helix in Solution; M. Hirshberg, M. Levitt. Membranes: Applications of Multidimensional Solidstate NMR Spectroscopy to Membrane Proteins; A. Ramamoorthy, et al. Carbohydrate Structure: Conformation, Mobility, and Function of the N-linked Glycan in the Adhesion Domain of Human CD2; G. Wagner, et al. Abstracts from Course: Protein Structures Abstracts: Solution Structure of the ETS-domain from Murine Ets1: A Winged-helix-turn-helix Motif; L.W. Donaldson. Protein Interactions Abstracts: Designing Mutant Hemoglobins; M. Madrid, et al. Nucleic Acids and Nucleic Acid-Protein Interactions Abstracts: A Study on the Dynamics of a DNA Binding Protein; L.M. Horstink, et al. Poster Abstracts. 55 additional articles. Index.
Introduction; I. Kahane. Biology of Mollicutes; J.G. Tully. Molecular Biology of Spiroplasmas; J.M. Bové. Mycoplasmas in the Human Urogenital Tract; D. Taylor-Robinson. Mycoplasma Infections of Man; H. Brunner. Mycoplasmas as Immunomodulators; Y. Naot. Mycoplasmas-Animal Plasmas; R.F. Ross. Detection of Adherence of Ureaplasma urealyticum to Bovine Mucosa Fallopian Tube Cells in Culture; A.B. Saada, et al. Serological Identification of Mollicutes; J.G. Tully. Rapid Detection of PhloemRestricted Mollicutes; M. Garnier, et al. Detection and Identification of Mycoplasmas with Diagnostic DNA Probes Complementary to Ribosomal RNA; K.E. Johansson. Mycoplasmas in Cell Culture; M.F. Barile, S. Rottem. Development of a CaptureELISA for the Specific Detection of Mycoplasma pneumoniae in Patients' Material; B. Gerstenecker, E. Jacobs. Identification of Mollicutes by Immunoblotting; S.A. Horowitz. 3 additional articles. Index.
Hemostatis and Desmopressin: Molecular Mechanisms of Cellular Responses to DDAVP; S. Hashemi, et al. Pharmacology and Pharmacodynamics of Desmopressin: Toxicity of Desmopressin and Related Peptides; L.B. Kinter, et al. Desmopressin in Renal Disease: Control of Bleeding in Uremic Patients; Y. Sultan. Desmopressin and Platelets: Desmopressin in the Treatment of Congenital and Acquired Defects of Platelet Function; M. Cattaneo, P.M. Mannucci. Desmopressin and Surgery: Desmopressin, von Willenbrand Factor, and Surgery; M. Weinstein. Desmopressin and Blood Donation: Effects of Desmopressin on Normal Donors in Plasma Exchange Donations; R.J. Sassetti, B.C. McLeod. Clinical Applications of Desmopressin in Hemophilia and von Willenbrand's Disease: Intravenous and Subcutaneous Desmopressin; M. Kohler, G. Mariani. SideEffects and Adverse Reactions of Desmopressin: DDAVP and Tachyphylaxis in Healthy Subjects; V. Vicente, et al. Recapitulation: General Recapitulation and Search for a Consensus; P.M. Mannucci, et al. 33 additional articles. Index.
Structure of a Human Rhinovirus Complexed with its Receptor Molecule; N.H. Olson, et al. Cascade Regulation of Vaccinia Virus Gene Expression; B. Moss. Transcriptional Activation by the Adenovirus E1A Proteins; B.A. Lewis, T. Shenk. Mechanisms Regulating Nucleocapsid Formation of the Hepatitis B Viruses; R. Bartenschlager, H. Schaller. Transcriptional Activation by the Hepatitis B Virus X Protein; R. Lucito, R.J. Schneider. Transcription Factors of the ETS Family; K. Macleod, et al. Structure and Function of the Vesicular Stomatitis Virus RNA-Dependent RNA Polymerase; S. Barik, et al. RNA Synthesis and mRNA Editing in Paramyxovirus Infections; J. Curran, et al. Translational Regulation by Reovirus Structural Proteins; A.J. Shatkin, et al. The Regulation of Coronavirus Gene Expression; S.G. Siddell. Aspects of the Molecular Biology of Poliovirus Replication; J. Harber, E. Wimmer. 9 additional articles. Index.
Bioremediation - the use of microorganisms for environmental clean-up - is a technology that is experiencing a rapid phase of development. From the opening chapter of Perspectives in Bioremediation, on the nature of environmental site assessment, on to the genetic manipulation of native soil microorganisms, the international collection of authors provide an understanding of the current progress and limitations of technologies that are designed to help nature herself. The book draws together many different aspects of environmental remediation: the environmental engineer is introduced to the bacteria of contaminated environments and the ideas developing from genetic engineering; the environmental microbiologist can grasp site assessment and the predictive kinetic analysis of potentials. The book provides a clear and concise introduction to the nature of and potential for bioremediation to contribute to a critical global effort in eliminating contamination of the world's resources and to start to reverse decades of environmental mismanagement and neglect.
Aldehyde Dehydrogenases-The 1992 Perspective.- Metabolic Role of Aldehyde Dehydrogenase.- Effects of Aldehyde Products of Lipid Peroxidation on the Activity of Aldehyde Metabolizing Enzymes in Hepatomas.- Metabolic Interactions of 4-Hydroxynonenal, Acetaldehyde and Glutathione in Isolated Liver Mitochondria.- Biological Role of Human Cytosolic Aldehyde Dehydrogenase 1: Hormonal Response, Retinal Oxidation and Implication in Testicular Feminization.- Human Cytosolic Aldehyde Dehydrogenase in Androgen Insensitivity Syndrome.- The Use of Immortalized Mouse L1210/OAP Cells Established in Culture to Study the Major Class 1 Aldehyde Dehydrogenase-Catalyzed Oxidation of Aldehydes in Intact Cells.- Enhanced Transcription of the Cytosolic ALDH Gene in Cyclophosphamide Resistant Human Carcinoma Cells.- Attempts to Increase the Expression of Rat Liver Mitochondrial Aldehyde Dehydrogenase in E. coli by Altering the mRNA.- Preliminary Characterization of the Rat Class 3 Aldehyde Dehydrogenase Gene.- Human High-Km Aldehyde Dehydrogenase (ALDH3): Molecular, Kinetic, and Structural Features.- Overexpression or Polycyclic Aromatic Hydrocarbon-Mediated Induction of an Apparently Novel Class 3 Aldehyde Dehydrogenase in Human Breast Adenocarcinoma Cells and Its Relationship to Oxazaphosphorine-Specific Acquired Resistance.- Tumor-Associated Aldehyde Dehydrogenase (ALDH3): Expression in Different Human Tumor Cell Lines with and without Treatment with 3-Methylcholanthrene.- Sexual Differentiation in the Induction of the Class 3 Aldehyde Dehydrogenase.- Mouse Class 3 Aldehyde Dehydrogenases: Positive and Negative Regulation of Gene Expression.- Human Stomach Aldehyde Dehydrogenase, ALDH3.- Bovine Corneal Aldehyde Dehydrogenases: Evidence for Multiple Gene Products (ALDH3 and ALDHX).- Carbonyl-Metabolizing Enzymes and Their Relatives Recruited as Structural Proteins in the Eye Lens.- Members of the ALDH Gene Family are Lens and Corneal Crystalline.- Retinoic Acid Synthesis in the Developing Retina.- Human Liver High Km Aldehyde Dehydrogenase (ALDH4): Properties and Structural Relationship to the Yeast Glutamic ?-Semialdhyde Dehydrogenase.- Effect of Some Compounds Related to Disulfiram on Mitochondrial Aldehyde Dehydrogenase in Vitro and in Vivo.- Photoaffinity Labeling of Aldehyde Dehydrogenase from Horse Liver by P1-N6-(4-Azidophenylethyl) Adenosine-P2[4-(3-Azidopyridinio)Butyl] Diphosphate.- Aldehyde Dehydrogenase: Aldehyde Dehydrogenation and Ester Hydrolysis.- Is the Single Site Binding Model for Aldehyde Dehydrogenase an Oversimplification? The One-Site, Two-Site Debate Revisited.- Crystallization and Preliminary X-Ray Analysis of Bovine Mitochondrial Aldehyde Dehydrogenase and Human Glutathione-Dependent Formaldehyde Dehydrogenase.- Aldo-Keto Reductases: An Overview.- Location of an Essential Arginne Residue in the Primary Structure of Pig Aldose Reductase.- Cys298 Is Responsible for Reversible Thiol-Induced Variation in Aldose Reductase Activity.- Substrate Specificity of Reduced and Oxidized Forms of Human Aldose Reductase.- Kinetic Alteration of Human Aldose Reductase by Mutagenesis of Cysteine Residues.- Inhibition of Aldose Reductase by (2, 6-Dimethylphenylsulphonyl) Nitromethane: Possible Implications for the Nature of an Inhibitor Binding Site and a Cause of Biphasic Kinetics.- Sepiapterin Reductase and ALR2 ("Aldose Reductase") from Bovine Brain.- Polymorphisms of the Aldose Reductase Locus (ALR2) and Suseptibility to Diabetic Microvascular Complications.- Polycyclic Aromatic Hydrocarbons and Phenolic Antioxidants do not Significantly Induce Carbonyl Reductase in Human Cell Lines.- The Purification and Properties of a Novel Carbonyl Reducing Enzyme from Mouse Liver Microsomes.- Properties and Stereoselectivity of Carbonyl Reductases Involved in the Ketone Reduction of Warfarin and Analogues.- Activation of Pulmonary Carbonyl Reductase by Aromatic Amines and Pyridine Ring-Containing Compounds.- Unique Dihydrodiol Specific Dehydrogena...
The Etiology and Prevention of Aerodigestive Tract Cancers.- Epidemiology of Vitamin A and Aerodigestive Cancer.- Multiple Primary Squamous Carcinomas of the Upper Aerodigestive Tract.- Genetic and Environmental Interactions as Risks for Aerodigestive Cancers.- Alcohol: A Cocarcinogen in Head and Neck Malignancies.- Smokeless Tobacco and Aerodigestive Tract Cancers: Recent Research Directions.- Biologic Markers as Predictors of Risk in Aerodigestive Tract Cancers.- Hamster Lung Cancer Model of Carcinogenesis and Chemoprevention.- The Hamster Cheek Pouch Model of Carcinogenesis and Chemoprevention.- Culture Conditions Affect Expression of the ?6?4 Integrin Associated with Aggressive Behavior in Head and Neck Cancer.- Growth Factors and Other Targets for Rational Application as Intervention Agents.- Hyperplasia and Squamous Metaplasia in the Tracheobronchial Epithelium: Alterations in the Balance of Growth and Differentiation Factors.- Micronuclei as Intermediate End Points in Intervention.- Study Design for the Prevention of Aerodigestive Tract Cancers.- Participant Enrollment, Participation, and Compliance in Chemoprevention Trials.- A Population-based Trial of ?-Carotene Chemoprevention of Head and Neck Cancer.- Chemoprevention of Barrett's Esophagus and Oral Leukoplakia.- Carotene and Retinol Efficacy Trial: Lung Cancer Chemoprevention Trial in Heavy Cigarette Smokers and Asbestos-exposed Workers.- An Intervention Trial in High-Risk Asbestos-exposed Persons.- Chemoprevention-of Aerodigestive Epithelial Cancers.- Contributors.
Challenges and Opportunities in the Area of Environmental Biotechnology; G.S. Sayler. Advances in Sustainable Biotechnology: Global Trends Affecting Green Technology; D. Miller. Green Chemistry: Using Enzymes As Benign Substitutes for Synthetic Chemicals and Harsh Conditions in Industrial Processes; G.E. Nedwin. The State-of-The-Science in Environmental Biotechnology and Remediation: Phytoremediation Applications for Removing Heavy Metal Contamination from Soil and Water; B.D. Ensley, et al. The Role of Microbial PCB Dechlorination in Natural Restoration and Bioremediation; D.L. Bedard, H.M. Van Dort. Environmental Biotechnology at Home and Abroad: Environmental Biotechnology Issues in the United States Federal Government; D.J. Grimes. Environmental Monitoring, Risk Analysis, and Applications to Bioremediation: Environmentally Acceptable Endpoints: The Scientific Approach to Clean-Up Levels; D. Ritter. Advances in Wastewater Treatment Technology: Biotreatability Kinetics: A Critical Component in the Scale-Up of Wastewater Treatment Systems; C.P.L. Grady, Jr., et al. Summary: Biotechnology in the Sustainable Environment: A Review; J.J. Gauthier. 23 Additional Artricles. Index.
The metals industry was established in the Ural Mountains over two centuries ago. Seventy years ago, the town of Magnitogorsk was established, with US and Western assistance, to exploit the iron ore there. It became a symbol of USSR industry - and is now a symbol of air pollution. This volume describes the pollution in the region and the steps being taken to combat it.
Peeling the Onion; E. Block, et al. Health Promoting Phytochemicals in Citrus Fruit and Juice Products; A. Montanari, et al. Chemopreventive Agents in Foods; B. Stavric. Constituents of Wild Food Plants; A. Sotelo. Biology and Biochemistry of Underground Plant Storage Organs; H.E. Flores, T. Flores. Behavioral Determinants for the Ingestion of Food Phytochemicals; T. Johns. Phytochemicals and Wine Flavor; S.E. Ebeler. Food Colorants from Plant Cell Cultures; F. Cormier. Transgenic Manipulation of Edible Oilseeds; T. Voelker. Quantitative Microscopic Approaches to Carbohydrate Characterization and Distribution in Cereal Grains; R.G. Fulcher, et al. Index.
The materials dealt with in this volume include wood, concrete, various metals, composites, ceramics, and porous geological media. Obviously, the properties and serviceability of such materials vary widely, and an almost universal theme in their testing is that the properties depend on the scale at which the analysis or observation is made. At each scale, `probability' plays an important role, where the word `probability' is used in a wider sense than the classical one. The book begins with a review of progress over recent years, identifying key questions that remain open. One point is how to observe/measure material properties at different scales, and whether a probabilistic approach, at each scale, is always applicable and advantageous. Obstacles to the identification of a universal approach include the wide range of materials and the diversity of applications. The hierarchical nature of materials and implications for modelling, testing and application are discussed extensively. Modern mathematical tools show considerable promise in attacking the multiscale nature of materials in modelling and testing, such as wavelet analysis, intersection methods for random sets, and truncated series expansion of random fields. Multiscaling is also discussed in the context of nonlinear dynamics. Furthermore, the concepts of scaling and criticality and their applicability in materials science create interesting points of view. Most contributions present both experimental and analytical/numerical results. A few are purely theoretical, and some are purely numerical.
Is There a Link between the Nature of Agents That Trigger Mast Cells and the Induction of Immunoglobulin (IG)E Synthesis?.- Immunogenetic Aspects of IgE-Mediated Responses.- Structure and Function of the Low Affinity IgE Receptor.- Characterization of the Human IgE Fc-Fce RIa Interaction.- The Analysis of Mast Cell Function in Vivo Using Mast Cell-Deficient Mice.- The Immunogenetic Basis of Collagen Induced Arthritis in Mice: An Experimental Model for the Rational Design of Immunomodulatory Treatments of Rheumatoid Arthritis.- Suppression of Experimental Autoimmune Myasthenia Gravis by Epitope-Specific Neonatal Tolerance.- T Cell Reactivity to Self and Allogeneic MHC-Peptides.- Antiribosomal Antibodies in SLE, Infection, and Following Deliberate Immunization.- Cross-Reactions of Anti-Immunoglobulin Sera with Synthetic T-Cell Receptor ? Peptides: Mapping on a 3-Dimension Model.- Stress Proteins in Autoimmunity.- Polyclonal B Cell Activation and B Cell Cross-Reactivity During Autoantibody Production in Systemic Lupus Erythematosus.- Autoantibody Activity and V Gene Usage by B-Cell Malignancies.- Naturally Occurring Human Autoantibodies to Defend T-Cell Receptor and Light Chain Peptides.- Natural Autoantibodies.- Regulatory Autoantibody and Cellular Aging and Removal.- B-Cell Origin of Cold Agglutinins.- Initiation of Autoimmune Type 1 Diabetes and Molecular Cloning of a Gene Encoding for Islet Cell-Specific 37KD Autoantigen.- Mapping of the Polypeptide Chain Organization of the Main Extracellular Domain of the ?-Subunit in Membrane-Bound Acetylcholine Receptor by Anti-Peptide Antibodies Spanning the Entire Domain.
QoS Enhancements and the New Transport Services; A. Danthine, et al. Performance Evaluation and Monitoring of Heterogenous Networks; J. Neuman, et al. Application of High Speed Networks in Hospital Environment; J.R. Rao. On Allocation Schemes for the Interconnection of LANs and Multimedia Sources over Broadband Networks; M. Mateescu. A Superposition of Bursty Sources in a LAN Interconnection Environment; J.M. Karlsson. Interconnecting LANs for Real Time Traffic Application; I. Chlamtac. An Analytical Model for ATM Based Networks which Utilize LookAhead Contention Resolution Switching; J.V. Luciani, C.Y. Roger Chen. Transient Analysis of Nonhomogenous Continuous Time Markov Chains Describing Realistic LAN Systems; A. Rindos, et al. Closed Queueing Network Modeling for End-to-End Performance Analysis of ISO LLC Transport Protocols over Bridged Networks; T. Ikegawa. A Preview of APPN High Performance Routing; J.P. Gray, M.L. Peters. 12 additional articles. Index.
Fluoropyrimidine Metabolism and Mechanism of Action.- 5-Fluoro-2?-Deoxyuridine: Role of Schedule in its Therapeutic Efficacy.- Comparison of Continuous Infusions and Bolus Injections of 5- Fluorouracil with or without Leucovorin: Implications for Inhibition of Thymidylate Synthase.- Critical Questions for the Future Direction of FU/LV.- Cellular Interactions Between the Natural and Unnatural Isomers of 5-Formyltetrahydrofolate.- Leucovorin as a Prodrug.- Clinical Use of Leucovorin: Intracellular Metabolism.- Some Considerations Concerning the Dose and Schedule of 5FU and Leucovorin: Toxicities of Two Dose Schedules from the Intergroup Colon Adjuvant Trial (INT-0089).- Effects of 5-Fluorouracil on mRNA.- Genetic Variation in Thymidylate Synthase Confers Resistance to 5-Fluorodeoxyuridine.- Experience with 5FU + L-Leucovorin.- 5-Fluorouracil Combined with the Pure [6S]-Stereoisomer of Folinic Acid in High Doses for Treatment of Patients with Advanced Colorectal Carcinoma: A Phase I-II Study of Two Consecutive Regimens.- 5-Fluorouracil Modulation in Colorectal Carcinoma: Experience of German Investigators.- An Overview of Adjuvant Treatment of Colon Cancer.- Dose-Dependent Inhibition of Aspartate Carbamoyltransferase in Peripheral Blood Mononuclear Cells in Patients Receiving N-Phosphonacetyl)-L-Aspartate.- Alternative Approaches to Modulation of Fluoropyrimidines.- Increasing the Efficacy of 5-Fluorouracil with Interferons: Preclinical, Clinical, and Pharmacokinetic Studies.- Enchanced Cytotoxicity of 5-Fluorouracil Combined with [6RS]-Leucovorin and Recombinant Human Interferon-?2a in Colon Carcinoma Cells.- Regulation of Thymidylate Synthase in Human Colon Cancer Cells Treated with 5-Fluorouracil and Interferon-Gamma.- Biochemical Modulation of 5-Fluorouracil by PALA: Mechanism of Action.- Implications of Chronobiology for 5-Fluorouracil (5-FU) Efficacy.- Update on Metabolic Modulation as a Therapeutic Approach for Adult Carcinomas.- Fluorouracil and Leucovorin in Advanced Breast Cancer.- Fluorouracil Modulation in Head and Neck Cancer.- Biomodulation in Head and Neck Carcinomas: Therapeutic Approaches in Europe.- Rationale for the Combination Therapy of 5FU and CDDP.- Biochemical Modulation of Fluoropyrimidines: The "Giscad" Studies.- New Drugs.- Clinical Experience with UFT in Japan.- Clinical Studies of the Modulation of Ftorafur.- The Role of the Reduced-Folate Carrier and Metabolism to Intracellular Polyglutamates for the Activity of ICI D1694.- The History of the Development and Clinical Use of CB 3717 and ICI D1694.- New Sites of Intervention in the Development of New Drugs in Solid Tumors.- P53: A Determinant of the Cell Cycle Response to DNA Damage.- Therapeutic Implications of Molecular Genetics.- Concluding Remarks.- Summary.- Abbreviations.- Author Index.
1 Vascular Analysis of the Carotid Body in the Spontaneously Hypertensive Rat.- 2 Role of the Carotid Sinus Nerve and of Dopamine in the Biochemical Response of Sympathetic Tissues to Long-Term Hypoxia.- 3 The Effects of Almitrine on [3H]5HT and [125I] Endothelin Binding to Central and Peripheral Receptors: An In Vitro Autoradiographic Study in the Cat.- 4 Immunocytochemical and Neurochemical Aspects of Sympathetic Ganglion Chemosensitivity.- 5 Neuronal and Neuroendocrine Markers in the Human Carotid Body in Health and Disease.- 6 The Effects of Chronic Hypoxaemia upon the Structure of the Human Carotid Body.- 7 Dopaminergic and Peptidergic Sensory Innervation of the Rat Carotid Body: Organization and Development.- 8 Effects of Cell-Free Perfusion and Almitrine Bismesylate on the Ultrastructure of Type-1 Cell Mitochondria in the Cat Carotid Body.- 9 Multi-Unit Compartmentation of the Carotid Body Chemoreceptor by Perineurial Cell Sheaths: Immunohistochemistry and Freeze-Fracture Study.- 10 Light and Electronmicroscopical Immunohistochemical Investigation of the Innervation of the Human Carotid Body.- 11 Serotonin (5-Hydroxytryptamine) Expression in Pulmonary Neuro-Endocrine Cells (NE) and a Netumor Cell Line.- 12 Effects of Hypoxia on Cultured Chemoreceptors of the Rat Carotid Body: DNA Synthesis and Mitotic Activity in Glomus Cells.- 13 Localization of Dopamine D2 Receptor mRNA in the Rabbit Carotid Body and Petrosal Ganglion by in situ Hybridization.- 14 Noradrenergic Glomus Cells in the Carotid Body: An Autoradiographic and Immunocytochemical Study in the Rabbit and Rat.- 15 The Modulation of Intracellular pH in Carotid Body Glomus Cells by Extracellular pH and pCO2.- 16 Evidence for Glucose Uptake in the Rabbit Carotid Body.- 17 Effects of Inorganic Calcium Channel Blockers on Carotid Chemosensory Responses in the Cat.- 18 Those Strange Glomus Cells.- 19 Carotid Body Neurotransmission.- 20 Carbonic Anhydrase and the Carotid Body.- 21 Ca2+ Dynamics in Chemoreceptor Cells: An Overview.- 22 Spectrophotometric Analysis of Heme Proteins in Oxygen Sensing Cell Systems.- 23 Neurochemical and Molecular Biological Aspects on the Resetting of the Arterial Chemoreceptors in the Newborn Rat.- 24 Carbonic Anhydrase and Carotid Body Chemoreception in the Presence and Absence of CO2-HCO3-.- 25 Role of Ion-Exchangers in the Cat Carotid Body Chemotransduction.- 26 Dopamine Metabolism in the Rabbit Carotid Body in vitro: Effect of Hypoxia and Hypercapnia.- 27 PO2-Dependence of Phospholipase C in the Cat Carotid Body.- 28 Optical Measurements of Micro-Vascular Oxygen Pressure and Intracellular pH in the Cat Carotid Body: Testing Hypotheses of Oxygen Chemoreception.- 29 Elevation of Cytosolic Calcium Induced by pH Changes in Cultured Carotid Body Glomus Cells.- 30 Role of Carbon Dioxide for Hypoxic Chemotransduction of the Cat Carotid Body.- 31 Metabolic Substrate Dependence of Carotid Chemosensory Responses to Stop-Flow Evoked Hypoxia and to Nicotine.- 32 Effects of Chemosensory Stimulation Membrane Currents Recorded with the Perforated-Patch Method from Cultured Rat Glomus Cells.- 33 Carbonic Anhydrase Near Central Chemoreceptors.- 34 Update on the Bicarbonate Hypothesis.- 35 Regulation of Intracellular pH in Type I Cells of the Neonatal Rat Carotid Body.- 36 Noradrenergic Inhibition of the Goat Carotid Body.- 37 Role of Substance P in Rat Carotid Body Responses to Hypoxia and Capsaicin.- 38 Carotid Sinus Nerve Inhibition Mediated by Atrial Natriuretic Peptide.- 39 Neurotransmitters and Second Messenger Systems in the Carotid Body.- 40 Does Adenosine Stimulate Rat Carotid Body Chemoreceptors?.- 41 Effects of Haloperidol on Cat Carotid Body Chemoreceptionin Vitro.- 42 Effect of Arterial Chemoreceptor Stimulation: Role of Norepinephrine in Hypoxic Chemotransmission.- 43 Carotid Body Denervation and Pulmonary Vascular Resistance in the Rat.- 44 Effects of Chemoreceptor Stimulation by Almitrine Bismesylate on Renal Function in Conscious Rats...
Regulation of Insulin Secretion.- Impaired Glucose-Induced Insulin Secretion: Studies in Animal Models with Spontaneous NIDDM.- Perturbation of Islet Metabolism and Insulin Release in NIDDM.- Regulation of Cytoplasmic Free Ca2+ in Insulin-Secreting Cells.- The ß-Cell Sulfonylurea Receptor.- Insulin, Insulin Receptors and Glucose Transporters.- Regulation of Glucose Transporters and the Na/K-ATPase by Insulin in Skeletal Muscle.- Insulin Receptor: Aspects of Its Structure and function.- The Diabetogenes Concept of NIDDM.- Molecular Genetics of NIDDM and the Genes for Insulin and Insulin Receptor.- Autoregulation of Glucose Transport: Effects of Glucose on Glucose Transporter Expression and Cellular Location in Muscle.- Insulin Action in NIDDM.- Insulin Resistance and the Pathogenesis of Non-Insulin Dependent Diabetes Mellitus: Cellular and Molecular Mechanisms.- Indirect Effects of Insulin in Regulating Glucose Fluxes.- The Insulin-Antagonistic Effect of the Counterregulatory Hormones - Clinical and Mechanistic Aspects.- On Insulin Action in Vivo: The Single Gateway Hypothesis.- Gluconeogenesis.- Acute Hormonal Regulation of Gluconeogenesis in the Conscious Dog.- Estimating Gluconeogenic Rates in NIDDM.- Glucose Metabolism during Physical Exercise in Patients with Noninsulin-Dependent (Type II) Diabetes.- Substrates and the Regulation of Hepatic Glycogen Metabolism.- Gluconeogenesis in Type 2 Diabetes.- Obesity, Lipoproteins, Atherogenesis, and NIDDM.- Regulation of Adipose Tissue Lipolysis, Importance for the Metabolic Syndrome.- Cellular and Molecular Factors in Adipose Tissue Growth and Obesity.- Regional Obesity and NIDDM.- Hyperinsulinemia and VLDL Kinetics.- Hyperinsulinism and Dyslipidemias as Coronary Heart Disease Risk Factors in NIDDM.- Potential Impact of New Concepts In NIDDM on Delivery of Care to Diabetic Populations.- A Paradigm to Link Clinical Research to Clinical Practice: The Challenge in Non-Insulin Dependent Diabetes Mellitus.
Theory of Ionization and Electron Emission: Theory of Electron Ejection from Matter by Highly Charged Ion Impact; J.H. Macek. Auger Processes at Metallic Surfaces: Auger Processes at Surfaces; A. Niehaus. Kinetic Auger Processes and Shell Effects: Electron Emission from Silicon Induced by Bombardment with Oxygen Ions; E.A. Maydell. Kinetic Electron Emission from Thin Foils: Electron Ejection Induced by Fast Projectiles; G. Schiwietz. Surface Effects in Kinetic Electron Emission: Electron Emission Phenomena in Grazing Collisions of Fast Ions with Surfaces; H. Winter, et al. Spin Polarized Electron Emission: IonInduced Electron Emission from Magnetic and Nonmagnetic Surfaces; C. Rau, et al. Electron Emission and Charging of Insulators: Secondary Electron Emission from Insulators; J. Schou. Ionization Effects in Semiconductors and Insulators: Ionization Tracks; R.E. Johnson. 23 additional articles. Index.
The Lectures: Conjugated Polymers in Layered Hosts; M.G. Kanatzidis, et al. Staging in Intercalated Graphites, Polymers, and Fullerenes; E.J. Mele. Seminars and Communications: Size-Mismatch Melting in Two Dimensions; N. Mousseau, M.F. Thorpe. Tight Binding Molecular Dynamics for Intercalation Chemistry; M. Menon, et al. Local Oscillator Model for Superconducting Fullerenes; Z. Gedik, S. Ciraci. Some Optical Properties of Fullerenes; B. Friedman. Photoluminescence of Solid State Fullerenes; H.J. Byrne, et al. Magnetic Properties of Alkali Metal Intercalated Fullerides; P. Byszewski, et al. Charge Transport and Percolation in Conducting Polymers; J. Voit. Overview on the Chemistry of Intercalation in Graphite of Binary Metallic Alloys; P. Lagrange. Mineralomimetic Inclusion Behavior of Cadmium Cyanide Systems; T. Iwamoto, et al. 36 additional articles. Index.
Background.- Aging, Comorbidity, and Breast Cancer Survival: An Epidemiologic View.- Squamous Cell Cancer of the Cervix, Immune Senescence and HPV: Is Cervical Cancer an Age-Related Neoplasm?.- Genetics and Epigenetics.- Genetic and Molecular Basis for Cellular Senescence.- A Single Gene Change Can Extend Yeast Life Span: The Role of ras in Cellular Senescence.- A Comparison of the Properties of Human P53 Mutant Alleles.- Gene Structure and Expression in Colorectal Cancer.- Influence of Physiological Changes in the Immune Constitutions in Aging and Cancer.- Tumors and Aging: The Influence of Age-Associated Immune Changes upon Tumor Growth and Spread.- T Cell Differentiation and Functional Maturation in Aging Mice.- Molecular Biology of Age-Related Changes in Some Types of Cancer.- I. Breast Cancer.- Cytogenetics and Clinical Correlations in Breast Cancer.- Breast Cancer: Influence of Endocrine Hormones, Growth Factors and Genetic Alterations.- Regulation of Estrogen Receptor Expression in Breast Cancer.- Aging and Development of Ovarian Epithelial Carcinoma: The Relevance of Changes in Ovarian Stromal Androgen Production.- II. Prostate Cancer.- Prostatic Cancer: An Age-Old Problem.- Stromal-Epithelial Paracrine Interactions in the Neoplastic Rat and Human Prostate.- Heparin-Binding Fibroblast Growth Factors and Prostate Cancer.- Molecular Epidemiology and Treatment Modality in Patients of Different Ages with Leukemias.- Age Related Changes in Adults with Acute Leukemia.- Significance of Chromosomal Chances in Patients of Different Age Groups with Acute Leukemia.- Glucocorticoid Receptors in Leukemias, Lymphomas and Myelomas of Young And Old.- Drug Resistance.- General Aspects of Cancer Chemotherapy in the Aged.- Drug Resistance and Cancer.- Summation and Synthesis.- From the Cancer Cell Biology Point of View.- From the Immunology Point of View.- From the Aging Point of View.- Participants and Contributors.
General Introduction: Dendritic cells: Antigen presentation, accessory function and clinical relevance.- Endocytic activity of dendritic cells is similar to other antigen presenting cells.- Immunocytochemical characterization of dendritic cells.- Requirements of exogenous protein antigens for presentation to CD4+ T lymphocytes by MHC Class II-positive APC.- Modulation of MHC Class II determinants on rat Langerhans cells during short term culture.- A dendritic cell specific determinant present in endosomes is involved in the presentation of protein antigens.- Dendritic cells are potent antigen-presenting cells for microbial superantigen.- Divergent T-cell cytokine profiles induced by dendritic cells from different tissues.- Adhesion molecules: Co-stimulators and Co-mitogens in dendritic cell - T cell interaction.- Dendritic cell dependent expression of IgA by clones in T/B microcultures.- Adhesion molecules in tonsil DC-T cell interactions.- Dendritic cells have reduced cell surface membrane glycoproteins including CD43 determinants.- The effect of human dendritic cells on the lectin-induced responsiveness of CD4+ T cells to IL-2 and IL-4.- Analysis of cytokine and cytokine receptor production by human dendritic cells.- Costimulating factors and signals relevant for antigen presenting cell function.- Distinct T cell stimulation mechanism and phenotype of human blood dendritic cells.- The role of dendritic cells in the regulation of T cell cytokine synthesis.- The role of dendritic cells as co-stimulators in tolerance induction.- The influence of dendritic cells on T-cell cytokine production.- Phenotypical and functional characterization of dendritic cells in the human peritoneal cavity.- Dendritic cells isolated from rat and human non-lymphoid tissue are very potent accessory cells.- Antigen presenting capacity of peritoneal macrophages and dendritic cells.- T-cell repertoire development in MHC class II deficient humans.- Rat thymic dendritic cells.- Rat thymic dendriticCells: flow cytometry analysis.- Ultrastructure of interdigitating cells in the rat thymus during Cyclosporin A treatment.- T cell tolerance and antigen presenting cell function in the thymus.- Tolerizing mice to human leukocytes: A step toward the production of monoclonal antibodies specific for human dendritic cells.- Morphological and functional differences between HLA-Dr+ peripheral blood dendritic cells and HLA Dr+ IFN-alpha producing cells.- Three monoclonal antibodies to antigen presenting cells in the rat with differential influence on cellular interactions.- The MHC expression of dendritic cells from mouse spleen isolated by centrifugal elutriation is unregulated during short term culture.- II-6 and its high affinity receptor during differentiation of monocytes into Langerhans cells.- Phagocytosis of antigens by Langerhans cells.- Dissection of human Langerhans cell allostimulatory function. Modulation by interferon-?.- Human in vitro T cell sensitization using hapten-modified epidermal Langerhans cells.- Monocyte-derived Langerhans cells from different species - morphological and functional characterization.- A serial section study of mice Langerhans cell granules after DNFB painting.- Skin dendritic cell-lymphocyte interactions in autologous system.- Induction of the low affinity receptor for IgE (Fc?RII/CD23) on human blood dendritic cells by interleukin-4.- Fc? RI mediates IGE-binding to human epidermal Langerhans cells.- Murine epidermal Langerhans cells as a model to study tissue dendritic cells.- Differentiation of dendritic cells in cultures of rat and mouse bone marrow cells.- TNF and GM-CSF dependent growth of an early progenitor of dendritic Langerhans cells in human bone marrow.- Human bone marrow contains potent stimulatory cells for the allogeneic MLR with the phenotype of dendritic cells.- Recombinant GM-CSF induces in vitro differentiation of dendritic cells from mouse bone marrow.- Signals required for differentiating dendritic cells...
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