Böcker i Neuromethods-serien

This handbook contains state-of-the art reviews of techniques for analysing post-translational protein modifications. The contributors provide detailed and specific methods for studying protein phosphorylation/dephosphorylation, methylation, fatty-acylation, ADP-ribosylation, and glycosylation.

Applied Neurogenomics

Covering the processes and potential of biosensors that can be implanted in the central nervous system for neurotransmitter detection, this book offers practical advice on technique, as well as insight on improved approaches and the advances they might bring.

Continuing the research of the best-selling first edition, this second edition collects three more years of research in the ever-expanding study of the cell membrane.

Animal models of schizophrenia and other major psychiatric disorders have been sought for decades and we now face new vistas on pathophysiology. Covering the key areas of research, this book explores the use of animal models in this difficult area of study.

Non-coding, inhibitory microRNAs have emerged as important modulators of cellular gene expression, through a process called RNA interference (RNAi).

The chapters discuss the use and interpretation of video-aided quantification of zebrafish behaviors, describe novel assays commonly used to quantify emotionality, learning, memory, and social behaviors in zebrafish, and instruct how to quantify endocrine responses and correlate them with behavior.

This authoritative book investigates a wide range of pain mechanisms. It seeks to lead scientists closer to the ultimate goal of improving the quality of life and relieving the unbearable burden of chronic pain for millions of people throughout the world.

Zebrafish Models in Neurobehavioral Research emphasizes the growing importance of zebrafish in neurobehavioral research and portrays an extensive, thorough perspective on the emergence of zebrafish as robust and translational models.

In view of the numerous failures of clinical trials aimed at improving stroke therapy, the role and potential benefit of experimentally modeling focal cerebral ischemia in rodents has been debated.

This methods volume gives detail on preparation of electrodes, practical experimental details and the interpretation of results, with a strong emphasis on applications to neurobiology.

As the presence of genetically modified animal models in research laboratories has multiplied, the role of genetic factors in the pathogenesis of brain disorders has become particularly important.

As fMRI technology has provided invaluable insights into the mechanisms through which the human brain works in healthy individuals and in patients with different neurological and psychiatric conditions, the study of brain function and even the monitoring of the effects of treatment have become more effective and efficient.

This volume provides in-depth descriptions and discussion of clinical trial designs based on novel data analysis of high-quality trials for 11 different neurological conditions in order to ultimately improve the quality of care in neurology.

This book provides readers with up-to-date information on the basic principles of molecular imaging and its major applications in clinical neuroscience. It includes key tips and expert guidance to ensure successful research results.

This volume highlights proteomics studies of quantitative PTM changes in both peripheral and central nervous system proteomes utilizing the most recent advances in mass spectrometry. Chapters include practical information pertaining to the fundamentals of sample preparation, liquid chromatography, and tandem mass spectrometry instrumental analysis and will elucidate best practices in the interpretation of data using modern bioinformatics approaches. Written for the popular Neuromethods series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory.Authoritative and practical, Analysis of Post-Translational Modifications and Proteolysis in Neuroscience aims to ensure successful results in the further study of this vital field.

This volume details methods for the analyses of specific lipid classes and lipidomics analyses of cells such as lymphocytes and oocytes.

Synapses underlie rapid and flexible neural communication in the brain and they hold the key to understanding higher brain functions in health and disease. The proposed volume brings together leading researchers to review these exciting new techniques and their application in neurobiological research.

Synapses underlie rapid and flexible neural communication in the brain and they hold the key to understanding higher brain functions in health and disease. The proposed volume brings together leading researchers to review these exciting new techniques and their application in neurobiological research.

Written for the popular Neuromethods series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory. Authoritative and practical, Neurotransmitter Transporters: Investigative Methods aims to ensure successful results in thefurther study of this vital field.

World-renowned researchers outline behavioral approaches used in characterizing mood and anxiety-related behaviors in mice as well as commonly used behavioral assays to assess the potential antidepressant and anxiolytic efficacy of novel compounds.

This Neuromethods series book reviews methods for generating lesions and for stimulating and inhibiting neural pathways, covering new techniques such as optogenetics and the use of the in situ perfused preparation and reassessing well-known approaches.

Epigenetic Methods in Neuroscience Research guides readers through methods for the analyses of chromatin remodeling, transposable elements, non-coding RNAs, such as miRNAs, and circadian oscillations, including: analysis of DNA methylation in neuronal and glial cells or small tissue samples;

World-renowned researchers outline behavioral approaches used in characterizing mood and anxiety-related behaviors in mice as well as commonly used behavioral assays to assess the potential antidepressant and anxiolytic efficacy of novel compounds.

Zebrafish (Danio rerio) play an integral role in biomedical research, enabling researchers to examine physiological mechanisms and pathways relevant to human pathogenesis and its therapy.

Later chapters describe how these paradigms are used to model the progression of drug addiction, providing insight into the clinical symptomatology of addiction from acquisition of drug use through compulsive drug taking to withdrawal and relapse.