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This book brings together contributions from key investigators in the area of osteoarthritic joint pain. It covers the clinical presentation of joint pain, the pathways involved in joint pain, osteoarthritis disease processes and pain, experimental models and pain control.

Chronic inflammation predisposes to some forms of cancer and the host response to malignant disease shows several parallels with inflammation and wound healing. The cells involved in inflammation are detected in a range of common cancers, together with the inflammatory cytokines and members of the chemokine ligand/receptor systems.

For the first time contributions are brought together from a multidisciplinary team of biologists and computer scientists to explore the issues related to immune function. This will help biologists apply new computer scientific methods to immunological research. The book considers practical applications (e.g.

This book draws together contributions from some of the leading investigators in the field of autism to consider specific problem areas in current research. Each contributor brings expertise from a different field, providing a balanced view of the whole spectrum of study of this disorder.

Over the last several years, immunologists have re-discovered the importance of regulatory lymphocytes, formerly termed 'suppressor cells'. Many recent reports have documented their existence, effector functions and potential therapeutic benefits in autoimmunity and transplantation.

Over recent decades vast amounts of biological data have been accumulated. However, it is becoming increasingly difficult to apply traditional theoretical methods to the formulation of coherent pictures of cell and organ function because it is no longer possible for a human theorist to integrate all of the available information.

This book explores the latest research on the role of the sarcoplasmic reticulum (SR) in smooth muscle function. It examines the control and modulation of the SR and how this may vary among smooth muscle types. Potential therapeutic implications are also discussed.

* This book is a comprehensive and up-to-date account of where we stand in immunological strategies for preventing or treating type 1 diabetes (T1D).

Understanding stem cells at the molecular level is essential to understanding their behaviour in a physiological context. This volume in our acclaimed Novartis Foundation series features animated discussion from the world's experts in this topic on the important ethical issues that are raised by research on stem cells.

Inflammatory bowel disease (IBD) comprises a group of idiopathic diseases of the intestine characterized by chronic inflammation of the bowel with periods of exacerbation and remission.

To understand the brain and its devastating diseases, we need to reveal the mechanisms that produce it and the ways in which it can constantly change throughout a lifetime. This book features a timely and insightful discussion between developmental neurobiologists and clinicians who deal with disorders of the nervous system.

Acetaldehyde-Related Pathology brings together contributions from experts working on all aspects of acetaldehyde-related pathology in order to better understand the pathogenesis of diseases in which acetaldehyde, from whichever source, is implicated.

Fatty Acid and Lipotoxicity in Obesity and Diabetes deals with the molecular aspects of fatty acid action in obesity and insulin resistance. The topics include lipid metabolism and adipose tissue biology, and beta-cell function and insulin resistance. Chapters deal with the molecular genetics and molecular physiology of energy homeostasis.

Much recent research in evolutionary developmental biology has focused on the origin of new body plans. However, most evolutionary change at the population and species level consists of tinkering: small-scale alterations in developmental pathways within a single body plan.

Contributors to this book explore existing strategies and examine possible new strategies for using the genome sequences of human, mouse, other vertebrates and human pathogens to solve outstanding problems in the treatment of immunological diseases and chronic infections.

This book brings together work from a wide range of disciplines to explain processes underlying empathy and fairness. It approaches the topic of empathy and fairness from different viewpoints, namely those of social cognitive neuroscience, developmental psychology, evolutionary anthropology, economics, and neuropathology.

This book features contributions from the world's leading researchers working on dengue and related flaviviruses who examine the current state of the art in the molecular biology of the dengue virus. Particular emphasis is placed on the structure and function of the virus and the targeting of virus proteins by potential antiviral agents.

Cl- absorption and HCO3- secretion are intimately associated processes vital to epithelial function, itself a key physiological activity. Until recently the transporters responsible remained obscure, but a breakthrough occurred with the discovery of the SLC26 transporters family.

Signalling Pathways in Acute Oxygen Sensing- No. 272 brings together contributions from experts in the field of acute oxygen sensing working on different tissues to address the controversies in the filed and their possible origins, and to develop approaches whereby these controversies might be resolved.

Seemingly simple behaviours turn out, on reflection, to be discouragingly complex. For many years, cognitive operations such as sensation, perception, comparing percepts to stored models (short-term and long-term memory), decision-making and planning of actions were treated by most neuroscientists as separate areas of research.

This title provides an extremely helpful analysis of genes that may be associated with autoimmunity, and answers questions such as how these genes can be identified, and how the functions of the gene products can be elucidated.

This book brings together contributions from key investigators in the area of pathological pain.

Nature employs a wide variety of sex determining mechanisms and it is only comparatively recently that the tools have become available for these to be explored at the cellular and molecular levels.

In vertebrates, the endocrine system plays a key role in conveying environmental temporal information to changes in physiology. This book reviews the biological basis of pulsatile hormone release, exploring the current state of knowledge of pulsatile hormone secretion in health and disease.

Functional genomics is the use of genetic information to design drugs. The ability to gather genetic data in the form of complete genetic sequences for certain organisms, has accelerated to astonishing speeds, reflecting the equally astonishing growth of information-gathering technologies.

Several fundamentally important questions form the basis for this book.

This important book covers the structure and molecular biology of small round structured viruses (SSRVs) such as caliciviruses and astroviruses, and the basic pathology of infection. It provides readers with the knowledge needed to make progress in the prevention and treatment of these infections.

The cell cycle is the sequence of events between mitotic divisions. The cycle is conventionally divided into G0, G1 (G stands for gap), S (synthesis phase during which DNA is replicated), G2 and M (mitosis). The sequence, as it appears in this text, is reviewed in relation to the development of living organisms from embryonic states to maturity.

Ageing at individual and population levels presents one of the greatest challenges to humankind as we begin the 21st century. Throughout the world, older adults are the fasts growing population group. Ageing is associated with an increased risk for development of chronic diseases that contribute to morbidity and mortality.

Chronic obstructive pulmonary disease (COPD), characterized by progressive chronic airflow obstruction, is the most common respiratory disorder of adults in the developed world and is the fourth main cause of death in the US. COPD has received little attention compared with other respiratory diseases such as asthma and lung cancer.