Böcker av Roger L. Lundblad

This brilliant work describes the application of protein modification to proteomic research, covering sample preparation, sample prefractionation, analytical technologies, and validation issues in depth. Written by a recognized expert, it merges current proteomics concepts into established solution protein chemistry concepts. The author gives parti

Examining the chemical modification of biological polymers and the emerging applications of this technology, Chemical Modification of Biological Polymers reflects the change in emphasis in this subsection of biotechnology from the study of protein structure and function toward applications in therapeutics and diagnostics. HighlightsThe basic organic chemistry of the modification proteins, nucleic acids, oligosaccharides, polysaccharides, and their applicationsNew analytical technologies used to characterize the chemical modification of biological polymersIdentification of in vivo, non-enzymatic chemical modification of biological polymersSpecific chemical modifications to generate biopharmaceutical products This book covers the basics on the organic chemistry underlying the chemical modification of biopolymers, including updates on the use of various chemical reagents. It describes the current status of chemical modification of biological polymers and emerging applications of this technology in biotechnology. These technologies are important for the manufacture of conjugate proteins used in drug delivery, for the preparation of nucleic acid microarrays, and for the preparation of hydrogels and other materials used in tissue engineering.

Discussing the role of plasma proteins in current biotechnology, this book describes the protein composition of human plasma, the fractionation of plasma to obtain therapeutic proteins, and the analysis of these products. It delineates the path from plasma products to recombinant products, and highlights products from albumin, intravenous immunoglobins, and coagulation. It offers a comprehensive review of current techniques for the analysis of proteins including electrophoresis, chromatography, spectrophotometry, and mass spectrometry, as well as updates not published since 1975.

Includes chapters on the use of classical protein chemistry in food, the protein and carbohydrate chemistry of adhesives, glues and sealants, protein chemistry and hydrogels, and the use of chemical modification to prepare protein therapeutics. This book also demonstrates use and the development of biotech applications.