Böcker utgivna av Elsevier Science Publishing Co Inc

Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies brings current knowledge from an international team of experts on the science and clinical management of glioblastoma chemoresistance. The book discusses topics such as molecular mechanisms of chemoresistance, experimental models to study chemoresistance, chemoresistance to drugs other than Temozolomide, and specific strategies to reverse chemoresistance. Additionally, it encompasses information on how to mitigate chemoresistance by targeted enhancement of p53 function. This book is a valuable resource for cancer researchers, oncologists, neuro-oncologists and other members of the biomedical field. Glioblastoma (GBM) is the most invasive and malignant primary brain tumor in humans with poor survival after diagnosis, therefore it is imperative that molecular and cellular mechanisms behind therapy resistant GBM cells, as well as the therapeutic strategies available to counter the resistance are comprehensively understood.

Takes an integrated approach from first principles, integrating cell biology, molecular biology, biochemistry, and health science Presents side topics of interest throughout ("gee whiz? topics) to give students quick mental breaks while still extending their knowledge in a practical sense Contains a greatly improved, robust teaching pedagogy to aid student learning Features new chapter learning objectives, chapter summaries, highlighted key terms, more end-of-chapter questions, and a new glossary

Starving Cancer Cells: Evidence-Based Strategies to Slow Cancer Progression - A Selection of Readings for Health Services Providers presents an edited and annotated collection of recent medical journal publications and abstracts illustrating new approaches to treatment derived from the metabolic theory of cancer. It intends to shed an early light on a relatively new approach to our understanding of the cancer cell idiosyncratic metabolic dysfunction, and on evidence-based new treatment strategies derived from that understanding. The book discusses topics such as tumor starvation by L-arginine deprivation; L-canavanine depriving tumors of L-arginine in pancreatic, multiple myeloma and breast cancer; glucose deprivation and intermittent fasting; glutamine uptake in cancer; the relation of oxygen-starved cancer cells with aspartate; and reducing tolerance of tumor cells to nutrition starvation. The content is presented in a contextualized and practical way in order to facilitate the transition from bench to bedside. This is a valuable resource for practitioners, oncologists and other members of healthcare chain who are interested in learning more about the most recent tumor cell starvation strategies and how they can improve overall treatment outcome.

Landscape Evolution: Landforms, Ecosystems and Soils asks us to think holistically, to look for the interactions between the Earth's component surface systems, to consider how universal laws and historical and geographical contingency work together, and to ponder the implications of nonlinear dynamics in landscapes, ecosystems, and soils. Development, evolution, landforms, topography, soils, ecosystems, and hydrological systems are inextricably intertwined. While empirical studies increasingly incorporate these interactions, theories and conceptual frameworks addressing landforms, soils, and ecosystems are pursued largely independently. This is partly due to different academic disciplines, traditions, and lexicons involved, and partly due to the disparate time scales sometimes encountered. Landscape Evolution explicitly synthesizes and integrates these theories and threads of inquiry, arguing that all are guided by a general principle of efficiency selection. A key theme is that evolutionary trends are probabilistic, emergent outcomes of efficiency selection rather than purported goal functions. This interdisciplinary reference will be useful for academic and research scientists across the Earth sciences.

Constitutive Modeling of Engineering Materials provides an extensive theoretical overview of elastic, plastic, damage, and fracture models, giving readers the foundational knowledge needed to successfully apply them to and solve common engineering material problems. Particular attention is given to inverse analysis, parameter identification, and the numerical implementation of models with the finite element method. Application in practice is discussed in detail, showing examples of working computer programs for simple constitutive behaviors. Examples explore the important components of material modeling which form the building blocks of any complex constitutive behavior.

Macromolecular Engineering: Design, Synthesis and Application of Polymers explores the role of macromolecular engineering in the development of polymer systems with engineered structures that offer the desired combination of properties for advanced applications. This book is organized into sections covering theory and principles, science and technology, architectures and technologies, and applications, with an emphasis on the latest advances in techniques, materials, properties, and end uses ¿ and including recently commercialized, or soon to be commercialized, designed polymer systems. The chapters are contributed by a group of leading figures who are actively researching in the field.  This is an invaluable resource for researchers and scientists interested in polymer synthesis and design, across the fields of polymer chemistry, polymer science, plastics engineering, and materials science and engineering. In industry, this book supports engineers, R&D, and scientists working on polymer design for application areas such as biomedical and healthcare, automotive and aerospace, construction and consumer goods.

Demonstrates the basic principles underlying the use of common experimental, chemometric, and statistical tools. This work emphasises problem-solving applications and the proper use and interpretation of data used for scientific research.