Advances in Cancer Biomarkers Research provides a thorough and detailed description of cancer biomarkers for diagnostic, prognostic and therapeutics in several cancer types. The book presents a compendium of topics related to current advanced research, along with fundamental knowledge that will help readers fully comprehend the field of cancer biomarkers. Topics discussed include such the role of genetic mechanisms, epigenetics, DNA and microRNA in different cancers, signaling pathways and exosomes. In addition, the book discusses biomarker research applied to several cancer types, such as head and neck, urological, lung, bone tumors, hematological and neurological malignancies and breast cancers.This will be a valuable resource for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in the potential of biomarkers in cancer research and treatment.
Molecular Biomarkers in Cancer Detection and Monitoring of Therapeutics: Volume Two: Diagnostic and Therapeutic Applications discusses how molecular biomarkers are used to determine predisposition, facilitate detection, improve treatment and offer prevention guidelines for different cancers. It focuses on novel diagnostic techniques based on molecular biomarkers and their impact on treatment, covering different cancer types such as tumors in the nervous system, head and neck, oral and GI tractor, lung, breast, gastric system, leukemia and urogenital tract cancers. For each type, the book discusses the best diagnostic techniques and therapeutic approaches, thus helping readers easily identify the best solution for each case. This is a valuable resource for cancer researchers, oncologists, graduate students and other members of the biomedical field who are interested in the potential of biomarkers in cancer research.
Molecular Biomarkers in Cancer Detection and Monitoring of Therapeutics, Volume One, Discovery and Technologies discusses how molecular biomarkers are used to determine predisposition, facilitate detection, improve treatment and offer prevention guidelines for different cancer types. This first volume in the series focuses on techniques and approaches recently developed to assist in the decision of which biomarker to use for specific conditions. Topics covered include circulating tumor cells and circulating tumor DNA, exomes, tumor microenvironment, gene editing, artificial intelligence and robotics. In addition, the book discusses the development and applications of organoids and precision medicine.This book will be a valuable resource for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in the potential of biomarkers in cancer research.
Natural Products in Vector-Borne Disease Management explores the potential application of natural products in vector control and disease management. The chapters discuss the global impact of specific vector-borne diseases, gaps in management, and natural products in specific stages of development - discovery, optimization, validation, and preclinical/clinical development. Toxic effects and mechanisms of action are also discussed. This book also explores how therapeutic plant derivatives can be used to combat the vectors of infection and how natural products can be used to manage and treat vector-borne diseases like malaria, leishmaniasis, dengue, and trypanosomiasis. With the inclusion of case studies on field and clinical applications and the contributions from experts in the field, Natural Products in Vector-Borne Disease Management is an essential resource to researchers, academics, and clinicians in parasitology, virology, microbiology, biotechnology, pharmacology, and pharmacognosy working in the field of vector-borne diseases.
Handbook of Epigenetics: The New Molecular and Medical Genetics, Third Edition provides a comprehensive analysis of epigenetics, from basic biology to clinical application. This new edition has been fully revised to cover the latest and evolving topics in epigenetics, with chapters updated and new chapters added on topics such as single-cell epigenetics, DNA methylation clocks in age-related diseases, transposable elements and epigenetics, X chromosome inactivation, and the epigenetics of drug addiction, among other topics. Throughout this edition, greater emphasis falls on epigenomic analyses and incorporating multi-omics approaches rather than gene-specific analyses. In addition, this edition has also been enhanced with step-by-step instructions in research methods, as well as easy-to-digest disease case studies and clinical trials that provide context and applied examples of recent advances in disease understanding and epigenetic therapeutics. These features empower researchers to reproduce the approaches and studies discussed and aid clinical translation. Live links across chapters tie in relevant external datasets and resources.
Viral Infections and Antiviral Therapies provides comprehensive coverage of viral infections and their transmission. Coverage includes antiviral agents, therapeutics, their mechanisms and treatment strategies. The book is organized into four sections, including an introduction to antiviral therapies, viral infections and their transmission, antiviral agents and therapeutics, and a market overview and future developments. The chapters in each section of the book discuss various key topics that are contributed to by an international group of leading experts.
Variety of bacteria are present in our environment but only a few of these bacteria causes diseases in their hosts including humans. These bacteria face different stresses in the environment as well as inside the host and adapt number of strategies for their survival. In 5 parts Bacterial Survival in the Hostile Environment covers all tactics and strategies adopted by bacteria for their survival under stressed conditions and will be focused on mechanistic insights of pathogenic adaptations to host environments (acidic environment, microaerobic conditions, immune system stress, metal stress etc., modulation of host pathways by pathogens for survival, dormancy, drug tolerance and resistance, proteins for stress survival). The content also includes different adaptation mechanisms of extremophiles to extreme environment, provides a complete and globally available advance knowledge related to bacterial survival from different perspectives and reviews the knowledge gaps and future prospects in the field of microbial adaptation for sustainable development of in the field of infection biology and pharmaceutics.
Get a broad overview of the different modalities of immersive video technologies¿from omnidirectional video to light fields and volumetric videöfrom a multimedia processing perspective. From capture to representation, coding, and display, video technologies have been evolving significantly and in many different directions over the last few decades, with the ultimate goal of providing a truly immersive experience to users. After setting up a common background for these technologies, based on the plenoptic function theoretical concept, Immersive Video Technologies offers a comprehensive overview of the leading technologies enabling visual immersion, including omnidirectional (360 degrees) video, light fields, and volumetric video. Following the critical components of the typical content production and delivery pipeline, the book presents acquisition, representation, coding, rendering, and quality assessment approaches for each immersive video modality. The text also reviews current standardization efforts and explores new research directions. With this book the reader will a) gain a broad understanding of immersive video technologies that use three different modalities: omnidirectional video, light fields, and volumetric video; b) learn about the most recent scientific results in the field, including the recent learning-based methodologies; and c) understand the challenges and perspectives for immersive video technologies.
Shaping the Future of Child and Adolescent Mental Health: Towards Technological Advances and Service Innovations coincides with the 25th International Association for Child and Adolescent Psychiatry and Allied Professions (IACAPAP) Congress in Dubai from December 5¿9, 2022. There are three overarching themes of this book. Firstly, the impact of the Internet and digital technologies on the mental health and well-being of children and adolescents, including computerized therapies, and the fundamental role of technologies to advance knowledge in the field. Secondly, a theme on harnessing the expansion of knowledge on psychiatric disorders and their treatment for children and adolescents, exemplified by chapters on different kinds of adversity in child and adolescent mental health and a chapter on precision therapeutics. Given the location of the IACAPAP Congress, the third theme focuses on aspects of child and adolescent mental health in the Eastern Mediterranean Region. Chapters provide insights into a broad range of contemporary technology- and service innovation¿related topics in child and adolescent psychiatry and mental health. These include growing up in the digital age, cyberbullying, clinical applications of big data and machine learning, computerized cognitive behavioral therapy, technology- enhanced learning, lessons from COVID-19, new understanding of the consequences of psychological trauma, autoimmune encephalitis, and precision therapeutics in depression. Acknowledging the global challenge of child and adolescent psychiatry and mental health, readers will find an emphasis on contextual challenges in the field, including innovations for scaling up of mental health intervention in low- and middle-income countries, and research and training in the Eastern Mediterranean Region.
Contemporary Management of Metastatic Colorectal Cancer: A Precision Medicine Approach summarizes current knowledge and provides evidenced-based practice recommendations on how to treat patients with metastatic colorectal cancer. The book presents topics such as pre-operating imaging, the use of molecular markers in treatment decisions, neoadjuvant therapy, synchronous colorectal liver metastasis, and minimally invasive approaches. In addition, it discusses immunotherapy, targeted therapies and survivorship. This is a valuable resource for practitioners, cancer researchers, oncologists, graduate students and members of biomedical research who need to understand more about novel treatments for colorectal cancer metastasis.
Metagenomics: Perspectives, Methods, and Applications, Second Edition provides thorough coverage of the growing field of metagenomics. Chapters from international experts examine methods for metagenomic analysis of microbiota, metagenomic computational tools, and recent metagenomic studies in various environments and clinical settings. This emphasis on applications makes the text particularly useful for applied researchers, practitioners, clinicians and students seeking to employ metagenomic approaches to advance knowledge in the biomedical and life sciences. Case-study based application chapters include topics ranging from viral metagenome profiling, metagenomics in oral disease and health, metagenomic insights into the human gut microbiome and metabolic syndromes, and more. This new edition has been fully updated to address the rapid growth and development of metagenomics applications that are discussed by experts who detail recent developments and fresh case studies. Newly added chapters instruct in methods and implications of metagenomics in areas of growing focus, such as microbiome research, clinical diagnosis, metagenomic epidemiology, wildlife conservation, zoonotic diseases and plant microbe interaction.
Genomics and the Global Bioeconomy, a new volume in the Translational and Applied Genomics series, empowers researchers, administrators, and sustainability leaders to apply genomics and novel omics technologies to advance the global bioeconomy and sustainability. Here, more than 15 international experts illustrate--with concrete examples across various industries and areas of global need--how genomics is addressing some of the most pressing global challenges of our time. Chapters offer an in-depth, case-based treatment of various topics, from genomics technologies supporting sustainability development goals to novel synthetic biology advancements improving biofuel production, conservation, sustainable food production, bioremediation, and genomic monitoring. Editors Catalina Lopez-Correa and Adrian Suarez-Gonzalez skillfully bring clarity to this diverse and increasingly impactful research, uniting various perspectives to inspire fresh innovation in driving the global bioeconomy. -- Provided by publisher.
Risk-informed Methods and Applications in Nuclear and Energy Engineering: Modelling, Experimentation, and Validation presents a comprehensive view of the latest technical approaches and experimental capabilities in nuclear energy engineering. Based on Idaho National Laboratory¿s popular summer school series, this book compiles a collection of entries on the cutting-edge research and knowledge presented by proponents and developers of current and future nuclear systems, focusing on the connection between modelling and experimental approaches. Included in this book are key topics such as probabilistic concepts for risk analysis, the survey of legacy reliability and risk analysis tools, and newly developed tools supporting dynamic probabilistic risk-assessment. This book is an insightful and inspiring compilation of work from top nuclear experts from INL. Industry professionals, researchers and academics working in nuclear engineering, safety, operations and training will gain a board picture of the current state-of-practice and be able to apply that to their own risk-assessment studies.
The behavior analytic research community emphasizes within-subject research methodologies to study relations between individual behavior and the environment. This is unique as behavior analytic practitioners can then replicate directly the research they read when determining whether a research finding applies to the clients with whom they work. Research Ethics in Behavior Analysis: From Laboratory to Clinic and Classroom is a reference guide for behavior analysts who conduct, supervise, or consume research specific to behavior analysis. This book is sequenced to follow the natural research process, beginning with an introduction to the history of research ethics that led to modern principles and values of scientific research ethics. The reader is taken through sequential steps from obtaining resources to support a research project through participant recruitment, conducting the study, communicating results, and supporting replication. Each chapter incorporates critical and under-discussed topics unique to research ethics in behavior analysis such as diversity, equity, and inclusion in the research process; balancing methodological rigor with clinical outcomes; aligning research and clinical goals; assessing generalization of research findings; the gray lines of assent and consent for intervention versus research; identifying and obtaining resources to support research; conflicts of interest; using technology and social media; and ethically handling data.
Modelling and Control Dynamics in Microgrid Systems with Renewable Energy Resources looks at complete microgrid systems integrated with renewable energy resources (RERs) such as solar, wind, biomass or fuel cells that facilitate remote applications and allow access to pollution-free energy. Designed and dedicated to providing a complete package on microgrid systems modelling and control dynamics, this book elaborates several aspects of control systems from classical approach to advanced techniques based on artificial intelligence. It captures the typical modes of operation of microgrid systems with distributed energy storage applications like battery, flywheel, electrical vehicles infrastructures that are integrated within microgrids with desired targets. More importantly, the techno-economics of these microgrid systems are well addressed to accelerate the process of achieving the SDG7 i.e., affordable and clean energy for all (E4ALL). This reference presents the latest developments including step by step modelling processes, data security and standards protocol for commissioning of microgrid projects, making this a useful tool for researchers, engineers and industrialists wanting a comprehensive reference on energy systems models.
Sustainable Development and Pathways for Food Ecosystems: Integration and Synergies is a science-based reference which focuses on several illustrated patterns that explore the roles played by the agri-food ecosystems, their functions and needs, and the importance of the interdependencies among them. This book explores the relationships and interdependencies between food ecosystems, highlighting the role each entity has in exploiting, transforming, preserving and conserving the others. It is a great resource of information on the ecosystems that surround the food supply chain and includes all processes from primary production of food through consumption.Sections cover the agricultural phase, processing and transformation, storage and consolidation, packaging, transportation and the management of waste and losses. This will be a useful reference for academicians, researchers and all the personnel involved with agri-food sector management.
Financial Trading and Investing, Third Edition provides a useful introduction to trading and market microstructure for advanced undergraduate as well as master¿s students. Without demanding a background in econometrics, the book explores alternative markets and highlights recent regulatory developments, implementations, institutions and debates. The text offers explanations of controversial trading tactics (and blunders) such as high-frequency trading, dark liquidity pools, fat fingers, insider trading and flash orders, emphasizing links between the history of financial regulation and events in financial markets. It includes coverage of valuation and hedging techniques, particularly with respect to fixed income and derivative securities. The text adds a chapter on financial utilities and institutions that provide support services to traders and updates regulatory matters. Combining theory and application, this book provides a practical beginner's introduction to today's investment tools and markets with a special emphasis on trading.
Venous Ulcers, Second Edition, provides a comprehensive synthesis of evidence-based recommendations and the highest level of expertise from a leading group of doctors, which is a fundamental constituent for the appropriate management of nonhealing venous wounds in everyday practice. This book offers a fertile environment for a complete understanding of genetics and molecular and biochemical mechanisms that lead to the development and progression of venous ulcers, which is essential for elucidating the underlying pathophysiology and can be utilized for developing novel therapies and accessing previously inaccessible areas of research. Socioeconomic impact, impact on health-related quality of life, the clinical course of the disease, and diagnostic algorithms are elaborated in detail. All currently available treatment modalities are explained in a clinically applicable approach with particular emphasis on operative technique, technical feasibility, success rates (both clinical and technical), and side effects. Lastly, this book elaborates on special diagnostic considerations and management of the most complex patients, often requiring the highest level of expertise for successful treatment.
Medicinal Chemistry of Chemotherapeutic Agents: A Comprehensive Resource of Anti-infective and Anti-cancer Drugs focuses on the basics and fundamentals of chemistry involved in chemotherapeutic agents. Each chapter comprises distinct chemical classifications that include structure and IUPAC nomenclature, synthetic schemes and routes for each drug, mechanism of the drug action, metabolic pathway and structure¿activity relationship (SAR) studies. The book covers current research focused on drug resistance and methods to overcome it, the development of newer drugs belonging to each category of the chemotherapeutic agents, molecules currently under clinical trials, and newly approved drugs, if any. This book will be a valuable resource for academics and researchers, helping them to understand the fundamentals of the medicinal chemistry of the chemotherapeutic agents.
Comprehensive Guide to Heterogeneous Networks discusses the fundamental motivations behind this cutting-edge development, along with a brief discussion on the diverse definitions of HNs. The future of heterogeneous wireless networks (HWNs) is covered, including test cases, cost configuration, economic benefits and basic challenges. Other sections cover the topology management method in context of heterogeneous sensor nodes with diverse communication and sensing range. In addition, an outline of the pros and cons of the clustering criteria in HWSNs and taxonomy are summarized and provide futuristic research directions. Final sections discuss the future evolution of HNs and their implementations in diverse applications. This is an essential reference book for advanced students on courses in wireless communications, clinical engineering and networking. It will also be of interest to researchers, network planners, technical mangers and other professionals in these fields.
Digital Therapeutics for Mental Health and Addiction: The State of the Science and Vision for the Future presents the foundations of digital therapeutics with a broad audience in mind, ranging from bioengineers and computer scientists to those in psychology, psychiatry and social work. Sections cover cutting-edge advancements in the field, offering advice on how to successfully implement digital therapeutics. Readers will find sections on evidence for direct-to-consumer standalone digital therapeutics, the efficacy of integrating digital treatments within traditional healthcare settings, and recent innovations currently transforming the field of digital therapeutics towards experiences which are more personalized, adaptable and engaging. This book gives a view on current limitations of the technology, ideas for problem-solving the challenges of designing this technology, and a perspective on future research directions. For all readers, the content on cultural, legal and ethical dimensions of digital mental health will be useful.
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