Protein Kinase Inhibitors: From Discovery to Therapeutics offers a foundational, pragmatic overview of protein kinases inhibitors and their potential role in disease modulation and treatment. Here, international experts in the field offer an integrated discussion of kinase inhibitor biology, biomarker discovery, and methods for drug design and development. After a brief overview of kinases and kinase inhibitors, subsequent chapters discuss individual kinases that are representative of the wider kinases and kinase families, including their roles in disease pathogenesis, underlying mechanisms, potential inhibitors and their modes of action for therapeutic modulation. Several potential drugs under different stages of clinical trials are discussed, including their relevance to cancer, diabetes, obesity, cardiovascular, neurological, and auto-immune and inflammatory disease, among other disorders. The book also addresses the challenges and opportunities for future kinase inhibitor development.
Contemporary Medical Biotechnology Research for Human Health discusses a range of currently available solutions required to defeat the ever-increasing human health challenges. The junction between biotechnology and biomedical/health sciences has led to several improvements in patients¿ treatment, diagnosis and well-being. The book discusses vital topics ranging from biofilms and UTI, mycobacterial infections, diabetes, aplastic anemia, oral cancer, and possible applications of nanoparticles. In addition, it discusses computer-aided drug design using natural products and new technologies to develop antibiotics. This is a valuable resource for biotechnology and biomedical researchers, bioinformaticians and members of health sciences interested in understanding recent technological developments.
Artificial Intelligence, Machine Learning, and Mental Health in Pandemics: A Computational Approach provides a comprehensive guide for public health authorities, researchers and health professionals in psychological health. The book takes a unique approach by exploring how Artificial Intelligence (AI) and Machine Learning (ML) based solutions can assist with monitoring, detection and intervention for mental health at an early stage. Chapters include computational approaches, computational models, machine learning based anxiety and depression detection and artificial intelligence detection of mental health. With the increase in number of natural disasters and the ongoing pandemic, people are experiencing uncertainty, leading to fear, anxiety and depression, hence this is a timely resource on the latest updates in the field.
Carbon Dots in Agricultural Systems integrates and crystallizes the emerging knowledge and application strategies of carbon dots as a powerful tool in agriculture systems. The book includes practical insights into the synthesis of carbon dots from indigenous raw materials and how to employ them in agriculture systems to increase crop productivity and provide renewable and cost-effective strategies that meet agricultural needs. Presented by an international team of experts, this resource updates on the latest in synthesis, physical, chemical and optical properties, along with the effects and mechanisms of carbon dots, all further explained in real-world studies. Finally, the book highlights emerging innovative topics which are of great relevance to scientists, academicians and innovators in agriculture (soil science, agricultural chemistry and agronomy) and biotechnology for further research and development.
Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging is a comprehensive and timely book on all aspects of anti-aging strategies. The book provides comprehensive, foundational knowledge on the mechanisms of aging and current anti-aging strategies and approaches developed. Aging research has experienced an unprecedented advance over recent years with the discovery that the rate of aging is determined, at least to some extent, mainly by our genetics and modulated by environmental factors. The hallmarks of aging describe the molecular and cellular processes that govern biological aging and their variation in individuals.
Redox Chemistry and Biology of Thiols offers an applied, comprehensive overview of redox chemistry and biology of thiol-dependent processes. Running from basic biology and chemistry of redox phenomena to research methods and highlighting recently identified roles of thiols across cellular and bodily systems, this book draws upon a range of disciplines to illuminate new research directions, new applications of thiol studies, and clinical translation. Sections cover thiol oxidizing species, thiol reactivity and modifications, thioredoxin, glutaredoxin, glutathione, peroxidases, thiol repair enzymes, thiol oxidative signaling, disulfide bond formation, thiol-based redox biosensors, cysteine and hydrogen sulfide metabolism, iron-sulfur cluster biogenesis, thiols in chloroplasts, blood thiols, sugar and polyamine thiols in pathogenic organisms, redox medicine (therapeutic applications of thiols and drug development), as well as methods and bioinformatics tools.
Combinational Therapy in Triple Negative Breast Cancer discusses TNBC at the molecular level with a holistic approach, focusing on combinational strategies targeting various pathways involved in this specific cancer type. Using a monotherapy for the treatment of cancer, especially high-grade tumors like TNBC, is mostly worthless due to the inherent genetic instability of tumor cells to develop intrinsic and acquired resistance; combination therapy presents more, or at least the same, effectiveness with lower doses of every single agent and decreases the likelihood of chemoresistance, making essential to understand more about multiple therapies options. The book is a valuable resource for cancer researchers, oncologists, graduate students, and members of biomedical field who are interested in the potential of combinational therapies to treat triple negative breast cancer. Presents up to date and cutting-edge knowledge of Triple negative breast cancer (TNBC) biology, clinical aspects, and treatment options Discusses novel targets and pathways involved in TNBC Provides insights and approaches for future research on TNBC
Stem Cells and COVID-19 presents up-to-date knowledge on the effect of hematopoietic and mesenchymal stem cells to combat SARS-CoV-2 infection in its diagnosis, treatment and prevention. In addition, the book critically discusses challenges, highlighting outstanding questions and future perspectives. Written by global experts in the field for both pre-clinical and clinical practitioners, this comprehensive book delves into how stem cells have a strong potential in developing better diagnostic, treatment and preventive strategies in SARS-CoV-2 infection. Both hematopoietic and mesenchymal stem cells are critical to better understand the response of immune system to coronavirus infection in both healthy and co-morbid conditions in the development of effective vaccines and immunotherapies.
Feedback Control for Personalized Medicine provides ideas on ongoing efforts and obstacles by members of the control engineering community in different biological and medical applications. In addition, the book presents key challenges, insights, tools and theoretical developments that arise from personalized medicine, along with medical concepts that are explained by engineers to help non-experts follow research topics. Several clinical trials have tried to find therapeutic approaches to achieve eradication or at least lifelong, therapy-free, host control of the infection. This has been performed integrating clinical observations, empirical knowledge and information from medical tests to treat patients. As this ¿trial and error approach is becoming more challenging and unfeasible by the steep increase in the number of different pieces of information and the complexity of large datasets, a systematic and tractable approach that integrates a variety of biological and medical research data into mathematical models and computational algorithms is crucial to harness knowledge and to develop new therapies towards personalized medicine.
Solar Energy Advancements in Agriculture and Food Production Systems aims to assist society and agricultural communities in different regions and scales to improve their productivity and sustainability. Solar energy, with its rapidly growing technologies and nascent market, has shown promise for integration into a variety of agricultural activities, providing an alternative, sustainable solution to current practices. To meet the future demands of modern sustainable agriculture, this book addresses the major existing problems by providing innovative, effective, and sustainable solutions using environment-friendly, advanced, energy-efficient, and cost-optimized solar energy technologies. This comprehensive book is intended to serve as a practical guide for scientists, engineers, policymakers, and stakeholders involved in agriculture and related primary industries, as well as sustainable energy development, and climate change mitigation projects. By including globally implemented solar-based agriculture projects in each chapter and highlighting the key associated challenges and benefits, it aims to bridge the knowledge gap between the market/real-world applications and research in the field.
Pseudokinases, Volume 667, the latest release in the Methods in Enzymology serial, highlights new advances in the field with this new volume presenting interesting chapters, including the Production and Purification of the PEAK pseudokinases for structural and functional studies, Structural biology and biophysical characterization of Tribbles pseudokinases, Detecting endogenous TRIB protein expression and its downstream signaling, Analysis of human Tribbles 2 pseudokinase, Expression, purification and examination of ligand-binding to IRAK pseudokinases, Characterization of pseudokinase ILK-mediated actin assembly, Biochemical examination of Titin pseudokinase, Approaches to study pseudokinase conformations, CRISPR editing cell lines for reconstitution studies of pseudokinase function, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Methods in Enzymology serials Includes the latest information on Pseudokinases
Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma: Translational and Clinical Outcomes, Volume Three provides comprehensive information about ongoing research and clinical data on liver cancer. The book presents detailed descriptions about diagnostics and therapeutic options for easy understanding, with a focus on precision medicine approaches to improve treatment outcomes. This updated volume discusses topics such as clinical and safety assessment of HCC patients, liver transplantation as a therapeutic option, immunotherapy interventions, and image-based surveillance. In addition, it discusses immunohistology of HCC-enabled precision medicine and artificial intelligence for hepatocellular carcinomas. This is a valuable resource for cancer researchers, oncologists, graduate students, hepathologists and members of biomedical research who need to understand more about liver cancer to apply in their research work or clinical setting.
Next Generation Nanochitosan: Applications in Animal Husbandry, Aquaculture and Food Conservation provides comprehensive and state-of-the-art-information on the application of nanochitosan for improving products, especially for the evaluation of biological active molecules, disease therapeutics, transport vehicle for DNA, targeted drug delivery, gene therapy, development of smart and high performance of fish, preservation of foods, tissue engineering, and improving the taste of aquatic and animal feeds as fish growth promoter. this book will be especially useful for industrial fisheries who deal with wild capture fishing and aquafarming and scientists and engineers working on post-capture processing stages. Details on the application of nanochitosan as an effective delivery of vaccines, hormones, vitamins, nutrients and antioxidants, biological active constituents and their wider application for the protection and management of farm animals and fishes against disease-causing pathogens are provided.
Implementation of Smart Healthcare Systems using AI, IoT, and Blockchain provides imperative research on the development of data fusion and analytics for healthcare and their implementation into current issues in a real-time environment. While highlighting IoT, bio-inspired computing, big data, and evolutionary programming, the book explores various concepts and theories of data fusion, IoT, and Big Data Analytics. It also investigates the challenges and methodologies required to integrate data from multiple heterogeneous sources, analytical platforms in healthcare sectors. This book is unique in the way that it provides useful insights into the implementation of a smart and intelligent healthcare system in a post-Covid-19 world using enabling technologies like Artificial Intelligence, Internet of Things, and blockchain in providing transparent, faster, secure and privacy preserved healthcare ecosystem for the masses.
Single-Port Robotic Surgery in Urology: The New Beginning After the Advent of Dedicated Platforms describes the novel field of robotic single-port urologic surgery. Recent advances in surgical robotics combined with the pursuit to reduce the invasiveness of laparoscopic surgery have led to the development of novel robotic platforms specifically designed for single-port surgery. This reference summarizes the state-of-the-art of robotic single-port urologic surgery. Coverage takes a three-part approach, providing a description of the technological evolution which led to the advent of novel platforms specifically designed for single-port surgery, describing the urological procedures that can be performed, and outcomes and potential drawbacks.
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