Social and Communicative Functioning in Populations with Intellectual Disability: A Developmental Perspective, Volume 65 in the International Review of Research in Developmental Disabilities series, focuses on social and communicative functioning with a particular emphasis on people with intellectual disability. The volume brings together international researchers across disciplines to highlight innovative approaches to holistically describe social and communicative abilities in this population including teleassessment, self-report, and community-engaged research designs. Through a lifespan approach, key issues are raised related to social and communicative functioning across a range of communication modalities from infancy through adulthood. Additional chapters cover Adaptation of in-person tools for remote assessment of infants and toddlers with social communication concerns in community-based settings, Measuring social communication in people with ID who use minimal speech: Differences across the lifespan, and Social Inclusion of Adults with IDD: Toward Belonging, Building a Life: Examining the advocacy and social experiences of students with IDD in inclusive postsecondary education.
Nanowired Delivery of Drugs and Antibodies for Neuroprotection in Brain Diseases with Co-morbidity Factors, Volume 171 in the International Review of Neurobiology series, highlights new advances in the field with this new volume presenting interesting chapters on Neurodegenerative diseases, Stress induced exacerbation of Alzheimer's disease brain pathology is thwarted by co-administration of nanowired cerebrolysin and amyloid beta peptide antibodies with serotonin 5-HT6 receptor antagonist SB-39988, Nanowired delivery of dl-3-n-butylphthalide with antibodies to alpha synuclein potentiated neuroprotection in Parkinson's disease with emotional stress, Efficacy of invasive and non-invasive methods for the treatment of Parkinson¿s disease: nanodelivery and enriched environment, and much more. Other sections cover Sleep deprivation induced exacerbation of Parkinson's disease pathophysiology is attenuated by co-administration of nanowired cerebrolysin and serotonin-3 receptor antagonist ondansetron, Co-administration of DL-3-n-butylphthalide and neprilysin is neuroprotective in Alzheimer disease associated with brain injury, Stress and brain diseases, Pathophysiology of sleep deprivation enhances amyloid beta peptide and p-tau in the CSF and brain, Neuroprotective effects of nanowired delivery of multimodal drug cerebrolysin and monoclonal 5-HT antibodies, Prior heat exposure exacerbates brain blast injury, Neuroprotection by nanodelivery of cerebrolysin with serotonin 6 receptor antagonist SB-399885, the Effects of curcumin nanodelivery on several brain pathologies, and more.
Stratigraphy and Timescales, Volume Eight in the Advances in Sequence Stratigraphy series, covers research in stratigraphic disciplines, including recent developments in the geosciences. This fully commissioned publication aims to foster and convey progress in stratigraphy with its inclusion of a variety of topics, including The fusulinids of a carbonate platform in Middle Permian Maokou Formation (Guadalupian) in eastern Sichuan Basin, China, Provenance of the Neogene sedimentary rocks of Sabah: the Kudat Formation, circular basins and the Crocker Unconformity revisited, The Neogene West Baram Delta, Ages and provenance of sedimentary rocks from Northwest Sulawesi and East Kalimantan: the Neogene Mahakam Delta, and much more.
Dystonia, Volume 169, the latest release in the International Review of Neurobiology serial, highlights new advances in the field with this new volume presenting interesting chapters on topics including Clinical Features and the Science of Classification, What Can Epidemiological Studies Tell us About the Neurobiology of Dystonia, Dystonia Genes and Their Biological Pathways, Functional Anatomy of Dystonia, Physiology of Dystonia: Human Studies, Physiology of Dystonia: Animal Studies, Experimental Pharmacology: Targeting Neurotransmitters, Experimental Pharmacology: Targeting Metabolic Pathways, Adult-Onset Focal Dystonias: One Biology or Many?, Early-Onset Inherited vs Late-Onset Idiopathic Dystonias: Same or Different Biological Mechanisms?, and much more.
Biofilms, Volume 53 in the ongoing Methods in Microbiology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of timely topics, including Monospecies and polymicrobial biofilms in static and flow environment, Methods used to study biofilms, Spatial analysis of bacterial biofilms, Biofilm grown in bioreactors, Single-cell analysis of subpopulations within biofilms using microscopy, flow cytometry, and imaging flow cytometry, Microscopy analysis of biofilm-mineral interactions or mineral formation within biofilms, Bacterial biofilms as an essential component of rhizosphere plant-microbe interactions, Studying Gene Expression in Biofilms, and more.
Handbook of Imaging in Multiple Sclerosis provides an up-to-date introduction into multiple sclerosis disease, including new findings on the pathophysiological processes, the clinical presentation, diagnosis, and treatment of the disease. This book includes in-depth chapters exploring the use of conventional and non-conventional imaging methods. These chapters cover magnetic resonance imaging (MRI) specific topics such as measurement of brain atrophy and susceptibility-weighted imaging. Additional chapters explore the use of additional imaging methods such as positron emission tomography (PET), optical coherence tomography (OCT) and high field MRI (use of 7T MRI scanners).
ZIP Metal Ion Transporters, Volume 684 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of topics, including Biochemistry, Biophysics and Structural Biology, Structure determination of a bacterial ZIP in lipidic cubic phase, Cell-based metal transport assay for animal and plant ZIPs, Measurement of metal binding affinity and transport activity in ZIP transporters using spectroscopic methods, Considerations in production of the (prokaryotic) ZIP family transporters for structural and functional studies, Metal-protein interactions investigated using model systems: thermodynamic, spectroscopic and computational methods, and more. Additional chapters cover Getting Zinc Into and Out of Cells, In-silico modeling of ZIP9 (TBD), Cellular Function and Regulation, Methods to visualize zinc transporter proteins of the SLC39A family in cells, Assessing metal ion transporting activity of ZIPs: intracellular zinc and iron detection, In vitro studies for studying manganese transport and homeostasis, and much more.
Phage Therapy - Part B, Volume 201 covers bacteriophage and their isolation, screening, synthetic phage, diagnostics, directed evolution, host interaction, and more. The book's aim is to highlight a number of aspects of phage in a way that can help students, researchers, clinicians, entrepreneurs and stakeholders perform research. Sections cover Phages for the treatment of Pseudomonas aeruginosa infection, Phage for the treatment of Vibrio cholerae infection, Phages for the treatment of Mycobacterium species, Phage therapy for gut microbiome, Phages as delivery vehicles, Phage display, Unlocking the potential of Phages: Innovative Approaches to harnessing Bacteriophages as Diagnostic Tools for Human Diseases, and more. Other sections explore Phage display and human disease detection, Bacteriophage as Cargo and its application in nanomedicine, Phage for drug delivery vehicles, Genome editing for phage design and uses for therapeutic applications, Phage for cancer therapy, and Phage for regenerative medicine and cosmetics.
Photoelectrochemical Engineering for Solar Harvesting: Chemistry, Materials, Devices provides an up-to-date appraisal of the photon engineering of innovative catalysts for solar energy harvesting. This book analyzes the overall progress, potential challenges, and the industrialization of new catalysts in the near future. The primary emphasis is on experimental approaches from materials synthesis to device applications, however, there is also an introduction to relevant photochemistry concepts. This book is suitable for materials scientists and chemists who, through the use of photonics, are in continuous pursuit of improving the efficiencies of different devices used to capture solar energy for the generation of sustainable fuel. Sunlight-driven fuel synthesis is the most sustainable and potentially economical option for producing energy vectors through water splitting. Thus, this book focuses on the design of photocatalysts and water oxidation catalysts, as artificial photosynthesis and hydrogen fuel production via water oxidation (in place of fossil fuels) are two promising approaches towards renewable energy.
Recapitulating The Stem Cell Niche Ex Vivo, Volume Six in the Advances in Stem Cells and their Niches series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Recapitulating the bone marrow stem cell niche ex vivo, The generation of the liver ex vivo, Recapitulating the thymic stem cell niche ex vivo, Recapitulating the intestinal epithelium stem cell niche ex vivo, Recapitulating the lung stem cell niche in vitro, Recapitulating mammary tissue in vitro, and Recapitulating muscle in vitro.
A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Third Edition is a valuable reference providing a complete understanding of all aspects of nonclinical toxicology in pharmaceutical research. This updated edition has been expanded and re-developed covering a wide-range of toxicological issues in small molecules and biologics. Topics include ADME in drug discovery, pharmacokinetics, toxicokinetics, formulations, and genetic toxicology testing. The book has been thoroughly updated throughout to reflect the latest scientific advances and includes new information on antiviral drugs, anti-diabetic drugs, immunotherapy, and a discussion on post-pandemic drug development challenges and opportunities. This is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings.
Cilia Signaling in Development and Disease, Volume 155 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Cilia and mTOR signaling, Cilia and Kidney, Extraciliary functions of IFT proteins, Cilia and eye stem cells, Cilia and eye development, Cryo-EM/ET and cilia structure, and Control of protein and lipid composition of photoreceptor outer segments and the implications for eye diseases.
Forensic Serology provides a comprehensive and complete synopsis of forensic serology. The book includes background information on different biological substances that can be detected, how the serological tests work, what the testing looks like, how to interpret the results, and what those results tell us. Coverage includes all aspects of serological testing, including basic presumptive testing, confirmatory testing, and new methods of testing, such as mRNA, methylation, proteomics, and much more. The book is written at a level that anyone with basic knowledge of science can fully understand, thus filling a gap in the market.
In this issue of Veterinary Clinics: Small Animal Practice, guest editor Dr. Joshua Stern brings his considerable expertise to the topic of Advancements in Companion Animal Cardiology. Cardiovascular disease of companion animals has seen a boom in research productivity and novel therapies that make the future of cardiac care very bright. In this issue, top experts highlight advances in diagnosis and treatment for common cardiac diseases such as hypertrophic cardiomyopathy, mitral valve degeneration, and dilated cardiomyopathy. Contains 12 relevant, practice-oriented topics including hypertrophic cardiomyopathy: advances in imaging and diagnostic strategies; the genetics of canine pulmonary valve stenosis; mitral valve repair: surgical outcomes and the rise of interventional options; the role of personalized medicine in companion animal cardiology; the role of point-of-care thoracic ultrasound in managing cardiac emergencies; and more. Provides in-depth clinical reviews on advancements in companion animal cardiology, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Nanofluids for Large-Scale Industrial Applications examines the challenges and current progress towards large-scale industrial application of nanofluids, summarizing and bringing together varied current research strands and providing potential solutions pertaining to the scientific, economic, and social barriers that currently exist. Opening with an introduction to nanofluid synthesis, types, and properties, this book traverses the potential large-scale applications and commercialisation of nanofluids in industrial heating/cooling, solar energy systems, refrigeration systems, automotive systems, and various chemical processes and manufacturing systems. This book provides knowledge of a vast area of applications of nanofluids in industries. Thus, it also has potential to encourage and trigger the minds of researchers to discover more about nanofluids, investigate the gaps, overcome the challenges, and provide future directions for newer applications and develop nanofluids further. The book is written chiefly for graduate/postdoc level students and researchers/academics teaching or studying in chemical and thermal engineering and who are focused on heat transfer enhancement, thermal energy, nanofluids, and nano-enhanced energy systems such as solar thermal systems.
Spectroscopic Measurement: An Introduction to the Fundamentals, Second Edition contains the foundational topics associated with optical spectroscopic techniques, covering the basic theory of applied spectroscopy and presenting alternative approaches to understand physical processes. Electromagnetism, quantum mechanics, statistical mechanics, molecular spectroscopy, optics, and radiation form the foundations of the field are all thoroughly covered. On top of these rest the techniques applying the fundamentals, including Emission Spectroscopy, Laser Induced Fluorescence, and Raman Spectroscopy. This comprehensive and fully updated second edition includes additional coaching and covers new material online broadening, nonlinear techniques such as coherent anti-Stokes Raman spectroscopy, and more.Researchers not formally trained in these topics, but who apply spectroscopy in their work, will appreciate the detail contained in this book to ensure accuracy of their technique and/or to develop more sophisticated measurements.
Antimicrobial Peptides: A Roadmap for Accelerating Discovery and Development covers the most important efforts of scientists and engineers worldwide to accelerate the process of discovery, production, and eventual market penetration of more potent antimicrobial peptides. These efforts have been fueled by emerging technologies such as artificial intelligence and data science, molecular and CFD simulations, easy-to-use process simulation packages, microfluidics, 3D-printing, among many others. Such technologies can now be implemented and scaled up quickly and at relatively low cost in low-budget production facilities, critical to moving to sustainable and marketable products worldwide. Discovering novel antimicrobial peptides rationally and cost-effectively has emerged as one of the significant challenges of modern biotechnology. Thus far, this process has been tedious and costly, resulting in molecules with activities far below those needed to address the current challenge of microbial resistance to antibiotics that takes the lives of thousands of people around the world every year. Finally, the book also highlights how multidisciplinary teams have assembled to address the challenges of manufacturing, biological testing, and clinical trials to finally reach complete translation.
3-Membered Heterocycle Synthesis provides readers with detailed information about the synthesis of three-membered heterocyclic compounds. The book comprehensively describes three-membered heterocyclic compounds synthesis, allowing the audience to quickly assess possible synthetic approaches. Other sections discuss their unusual combination of synthetic flexibility, reactivity, and atom economy. The main challenge for synthetic chemists, both in academia and industry, is the search for efficient approaches to target molecules. This book presents several methodologies for the synthesis of three-membered heterocyclic compounds.
Agroforestry for Carbon and Ecosystem Management is a comprehensive overview of current research, issues, challenges, and case studies in the area of agroforestry. The book focuses specifically on carbon source-sink relationship and management through agroforestry practices with a goal of improving overall environmental sustainability. Through expert insights and case studies, the book promotes carbon management, greenhouse gas emission reduction, forest, and ecosystem services management, along with relevant sustainable approaches for natural resources conservation. Users will find insights into novel approaches for natural resource management, with specific attention given to technologies related to carbon capture and management. In addition, the book addresses the knowledge gap in relation to agroforestry, sustainability, and agroecosystem management and explores the application of remote sensing and geospatial technologies for agroforestry management.
Practical Design and Applications of Medical Devices focuses on devices which receive and transmit bioelectric signals, such as electrocardiograph, electrodes, blood flow, blood pressure, physiological effects and, in some cases, current flowing through the human body. This thorough guide for researchers and engineers in the field of biomedical and instrumentation engineering presents a streamlined medical strategy for designing these medical devices, sensors, and tools. It also promotes operational efficiency in the healthcare industry, with the goals of improving patient safety, lowering overall healthcare costs, broadening access to healthcare services, and improving accessibility.
Computational Intelligence and Modelling Techniques for Disease Detection in Mammogram Images comprehensively examines the wide range of AI-based mammogram analysis methods for medical applications. Beginning with an introductory overview of mammogram data analysis, the book covers the current technologies such as ultrasound, molecular breast imaging (MBI), magnetic resonance (MR), and Positron Emission mammography (PEM), as well as the recent advancements in 3D breast tomosynthesis and 4D mammogram. Deep learning models are presented in each chapter to show how they can assist in the efficient processing of breast images. The book also discusses hybrid intelligence approaches for early-stage detection and the use of machine learning classifiers for cancer detection, staging and density assessment in order to develop a proper treatment plan. This book will not only aid computer scientists and medical practitioners in developing a real-time AI based mammogram analysis system, but also addresses the issues and challenges with the current processing methods which are not conducive for real-time applications.
The Water-Energy-Food Nexus: Optimization Models for Decision Making, Volume 32 covers water, energy, and food as crucial resources for human well-being and sustainable development. These resources are inextricably interrelated, therefore, to cover water, energy, and food demands in different sectors and at different scales, it must be considered several sources to produce resources, and the interlinkages of resources for a proper integration must be considered. This book emphasizes issues that must be considered in the design of water-energy-food nexus systems, such as the selection of technologies to produce water or energy, size of technologies, and food required for nutritional demands.In addition, mathematical models are presented for the design of water-energy-food nexus systems involving several strategies to account for issues such as sustainable development, security of resources, interest in conflicts from stakeholders, and efficient allocation of resources.
Impressive engineering advances have occurred that can curb the impact of seismic events on residential properties, commercial edifices, architectural heritage, and infrastructure. Written by a university professor with decades of on-site experience, Construction of Earthquake-Resistant Concrete and Steel Structures offers up-to-date information and technical competence with the aim of supporting an understanding of fundamental concepts for concrete and steel structures, shell elements, and reinforcement detailing. The volume is an invaluable resource for students, researchers, and early-career practicing professionals to also learn about construction issues and how to solve practical challenges while ensuring that building codes (ACI, AISC, ANSI, ASCE, RCSC, and many more) and design standards' requirements are upheld.
In this issue of Neurologic Clinics, guest editosr Drs. David L. Perez and Sara A. Finkelstein bring their considerable expertise to the topic of Functional Neurologic Disorders. Top experts in the field cover issues such as functional movement disorder: assessment and treatment; functional cognitive disorder: diagnosis, treatment, and differentiation from secondary causes of cognitive dysfunction; functional speech and voice disorders: diagnosis and treatment; personalizing clinical care in functional neurological disorder: a biopsychosocial-informed perspective; and more.In this issue of Neurologic Clinics, guest editosr Drs. David L. Perez and Sara A. Finkelstein bring their considerable expertise to the topic of Functional Neurologic Disorders. Top experts in the field cover issues such as functional movement disorder: assessment and treatment; functional cognitive disorder: diagnosis, treatment, and differentiation from secondary causes of cognitive dysfunction; functional speech and voice disorders: diagnosis and treatment; personalizing clinical care in functional neurological disorder: a biopsychosocial-informed perspective; and more.
Offering practical tips and expert answers to topics in dentistry, oral medicine, and patient management, Dental Secrets, 5th Edition serves as an ideal preparation tool for exams, clinical rotations, and board certification. A concise, illustrated Q&A format covers key areas such as oral pathology, radiology, periodontology, endodontics, restorative dentistry, prosthodontics, orthodontics, infection control, and oral and maxillofacial surgery. This mini reference makes it easier to prepare for real-world clinical scenarios and review for the INBDE and other certification exams! Dentistry's best "secrets" are shared by experts specializing in various areas of dentistry and oral medicine. Concise answers to more than 2,000 questions in dentistry and oral medicine provide valuable pearls, tips, memory aids, and "secrets" in an easy-to-read, numbered format. More than 100 illustrations, tables, and boxes highlight key takeaways. NEW! Brand-new chapter reveals "secrets" surrounding orofacial pain. NEW! Questions and examples are prepared with the new INDBE exam content in mind. NEW! A new group of contributing authors and a new co-editor - all leaders in the field of dentistry - bring a fresh perspective and valuable expertise to the text. NEW! An enhanced eBook, included with print purchase, provides access to all the text, figures, and references, plus the ability to search, customize content, make notes and highlights, and have content read aloud. UPDATED! Fresh revisions with the most current clinical information keep students, practitioners, and those preparing for recertification up to date on key advances in the practice of dentistry.
"Available to Pharmacy Technicians with at least three years of work experience, the Advanced Certified Pharmacy Technician (CPhT-Adv) credential provides a pathway for obtaining higher-level skills and advancing your career. This new resource gives you the review and practice you need to prepare for the exam with an easy-to-use format, sample certification exams, content review chapters, and more."--
The immune system is highly complex, it senses foreign invaders, thus protecting the body. The adaptive arm of the immune system confers long-term protection, whereas the innate immune system confers immediate protection. In the case of the immune system, the pattern recognition receptors offer various modes of sensing the molecular patterns associated with pathogens. Toll-like receptors (TLRs) are important mediators of inflammatory pathways in the gut which play a major role in mediating the immune responses towards a wide variety of pathogen-derived ligands and link adaptive immunity with the innate immunity. This book covers the role of TLRs in several vector-borne Diseases. Starting with an introduction to these diseases, the book explains the different types of receptors involved in these diseases. The diseases are then covered in separate chapters, including: malaria, lymphatic filariasis, visceral leishmaniasis, dengue fever, chikungunya, West Nile fever, and Japanese encephalitis. The book is a handy reference for researchers and trainees involved in clinical medicine and infection control. It can also serve as supplementary reading material for Students undertaking courses in biotechnology, public health, entomology, immunology, epidemiology, and life sciences.
Mineral Systems, Earth Evolution, and Global Metallogeny provides insights into the critical parameters of Earth's evolution, particularly in terms of thermal state, tectonics, and the atmosphere-hydrosphere-biosphere system that control the metallogeny of the planet. World-class to giant mineral systems are described and interpreted in terms of their relationship to critical periods of change in tectonic regimes within the supercontinent cycle and evolution of the mantle lithosphere. Specific times of formation of highly anomalous giant mineral systems, such as the so-called Boring Billion, are discussed together with specific tectonic environments, such as craton edges and thick lithosphere margins. This book provides an overview on how the evolution of Earth has dictated the nature and distribution of its mineral resources that are the foundation of our modern industries and provides insights into critical parameters for conceptual exploration targeting. Mineral Systems, Earth Evolution, and Global Metallogeny provides a helpful resource for researchers, academicians, undergraduate and graduate students, and geologists engaged in the fields of economic geology, geologic exploration, mineral systems, and earth evolution in understanding the timing and distribution of the world's major mineral deposits and their relation to critical parameters controlling earth's evolution.
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