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As mentioned in his memoirs, Cheiro acquired his expertise in India. As a teenager, he traveled to the Bombay port of Apollo Bunder. There, he met his Guru, an Indian Brahmin, who took him to his village in the valley of the Konkan region of Maharashtra. Later Cheiro was permitted by Brahmans to study an ancient book that has many studies on hands; the pages of the book were made of human skin and written with gold and it is still guarded and protected with great care. After studying thoroughly for two years, he returned to London and started his career as a palmist. Cheiro had a wide following of famous European and American clients during the late 19th and early 20th centuries. He read palms and told the fortunes of famous celebrities like Mark Twain, W. T. Stead, Sarah Bernhardt, Mata Hari, Oscar Wilde, Grover Cleveland, Thomas Edison, the Prince of Wales, General Kitchener, William Ewart Gladstone, and Joseph Chamberlain. He documented his sittings with these clients by asking them to sign a guest book he kept for the purpose, in which he encouraged them to comment on their experiences as subjects of his character analyses and predictions. Of the Prince of Wales, he wrote that "I would not be surprised if he did not give up everything, including his right to be crowned, for the woman he loved." Cheiro also predicted that the Jews would return to Palestine and the country would again be called Israel. In his own autobiographical book, Cheiro's Memoirs: The Reminiscences of a Society Palmist, he included accounts of his interviews with King Edward VII, William Gladstone, Charles Stewart Parnell, Henry Morton Stanley, Sarah Bernhardt, Oscar Wilde, Professor Max Muller, Blanche Roosevelt, the Comte de Paris, Joseph Chamberlain, Lord Russell of Killowen, Robert Ingersoll, Ella Wheeler Wilcox, Lillie Langtry, W. T. Stead, Richard Croker, Natalia Janotha, and other prominent people of his era.

Jonathan Swift, Dean of St. Patrick's Cathedral, Dublin, was an Anglo-Irish satirist, author, essayist, political pamphleteer, poet, and Anglican cleric. He wrote A Tale of a Tub (1704), An Argument Against Abolishing Christianity (1712), Gulliver's Travels (1726), and A Modest Proposal (1729). The Encyclopaedia Britannica considered Swift the most significant English prose satirist. He wrote all anonymously under pseudonyms and specialized in Horatian and Juvenalian satire. Deadpan, ironic writing, especially in A Modest Proposal, has led to the term "Swiftian." William Temple returned to Moor Park in 1691 after leaving Temple for Ireland due to health issues. He became an established Church of Ireland priest after earning his M.A. from Hart Hall, Oxford, in 1692. The Diocese of Connor appointed him prebend of Kilroot in 1694. Swift, who called Jane Waring "Varina," may have dated Waring in his remote community. He helped publish Temple's memoirs and correspondence after returning to England and Moor Park in 1696. Swift briefly edited his memoirs in England after Temple died in 1699. His work alienated Temple's family and friends, including his sister, Martha Lady Giffard. Swift tried to talk to King William but failed and became the Earl of Berkeley's secretary and chaplain. He wrote many of his works in Trim, County Meath. Trinity College Dublin awarded Swift a Doctor of Divinity in 1702. In October, Esther Johnson and Rebecca Dingley joined him in Ireland. Some believe Swift and Esther Johnson were secretly married, while others don't. Swift, an influential 17th-century politician, supported the Glorious Revolution and was initially a Whig. The return of the Catholic monarchy and "Papist" absolutism worried him. Swift published The Conduct of the Allies in 1711 after supporting the Tory government in 1710. Henry St. John and Robert Harley often consulted him as a Tory government insider. In London, Swift became involved with Esther Vanhomrigh, one of their daughters.