Böcker utgivna av Presses Polytechniques et Universitaires Romandes

Lipidomics forms part of the field of metabolomics, which in turn follows on from genomics, transcriptomics, and proteomics, in a top-down manner. It is the study of hydrophobic molecules called lipids; however, lipid molecular species are so numerous that investigators tend to subdivide global lipidomics into targeted lipidomic approaches. This book focuses on structural and mediator lipidomics, with a particular emphasis on their functional aspects. This includes lipids deserving of special interest for their structures (especially as parts of cell membranes or plasma lipoprotein particles) and lipids known for their biological activities, which mediate the action of cell agonists (for example, hormones, growth factors, etc.). The oxygenated metabolites of the major functional w6 and w3 polyunsaturated fatty acids in mammals, in particular arachidonic and docosahexaenoic acids, are presented, with special attention paid to their structure-function relationships. These metabolites are very active, and their biological relevance was recognized early on with a Nobel Prize in Physiology and Medicine in 1982. Finally, general principles for the high performance analysis and characterization of lipid species are also presented. The book has been written for undergraduate students and scientists interested in the field of lipids. Clinicians will also be able to find useful information, due to the numerous references to pathophysiology.

Building Cultures Valparaiso takes a critical look at how pedagogy, practice and poetry are brought together at one of the most influential schools of architecture of the past 50 years: the School of Architecture and Design of the Pontifical Catholic University of Valparaiso in Chile. The editors have brought together research on the origins of the school, on the role that poetry plays in teaching and practice, and on the school's larger historical place in the context of a global out-break of radical architectural teaching in the late 1960's. Contributors come from both within and outside of the school and include Beatriz Colomina, David Jolly Monge and Gerald Wildgruber. In addition to original research, Building Cultures Valparaiso includes a collection of student drawings from the early years of the Valparaiso School's Open City, a 270 hectare stretch of land along the Pacific Ocean that serves as a laboratory for living and working together. These drawings provide an insight into how the philosophy of the school translates into the making of architecture. Through its exploration of the Valparaiso School's radical approach to teaching and making, Building Cultures Valparaiso serves as a guide for all those interested in an experimental vision of architecture.