Böcker utgivna av Springer Basel

Here is a comprehensive overview of the development of Onbrez Breezhaler, a newly approved once-daily inhaled beta2 agonist for treating COPD. Covers design and pre-clinical pharmacology of the molecule, early clinical development, efficacy studies and more.

Galanin is a neuropeptide found both in the central and peripheral nervous system. The studies reviewed in this volume give a fairly complete overview of the spectrum of the biological actions and functions of galanin and its receptors and on possible therapeutic applications in a number of pathological conditions.

Building on the existing titles in the "Airways Smooth Muscle" sub-series, the sixth volume explores physiological and pharmacological processes in the lung in vivo. The various animal models available for studying the bronchospasm and inflammation associated with human asthma are thoroughly reviewed by internationally recognised scientists. Specific chapters focus on the problems of administering drugs to animal airways, the mechanics of assessing lung function in the models, and describe in detail the species used, from rodents to primates. The use of genetically altered animals, an area of particular interest to molecular biologists, is also considered in depth. This up-to-date and extensively referenced work will prove invaluable to pharmacologists, physiologists and other biological scientists at all levels in academia and in the pharmaceutical industry.

It is no longer time-consuming analysis of unknown products, but rather selective identifications of individual forms, modifications and processings, and overall analysis of global protein outputs from cells and tissues in health and disease.

Emil Artin and Helmut Hasse

This book presents the proceedings of a conference on dynamical systems held in honor of Jürgen Scheurle in January 2012. Through both original research papers and survey articles leading experts in the field offer overviews of the current state of the theory and its applications to mechanics and physics. In particular, the following aspects of the theory of dynamical systems are covered: - Stability and bifurcation- Geometric mechanics and control theory- Invariant manifolds, attractors and chaos- Fluid mechanics and elasticity- Perturbations and multiscale problems- Hamiltonian dynamics and KAM theoryResearchers and graduate students in dynamical systems and related fields, including engineering, will benefit from the articles presented in this volume.

The essential question that fractal dimensions attempt to answer is about the scales in Nature. For a system as non-idealistic and complex as a protein, studying scale-invariance becomes particularly important.Fractal Symmetry of Protein Exterior investigates the diverse facets of the various scales at which we describe protein biophysical and biochemical phenomena. Although these ideas are entirely mathematical, mathematical expositions have been avoided, unless the use of some expressions becomes absolutely obligatory. A first chapter introduce into fractal dimensions, protein exteriors and to methods to study the roughness of surfaces. The main topics covered in the following chapters include: protein-protein interaction interfaces; protein surface-roughness and local shape as well as adhesion on protein and other rough biomolecular surfaces.

The essential question that fractal dimensions attempt to answer is about the scales in Nature. For a system as non-idealistic and complex as a protein, studying scale-invariance becomes particularly important.Fractal Symmetry of Protein Interior investigates the diverse facets of the various scales at which we describe protein biophysical and biochemical phenomena. Following a thorough introduction to fractal dimensions, fractal-dimension-based approaches, that have been employed to study protein interior biophysical properties, are described. The focus is on the question "e;which scales are scale-invariant?"e; Investigations related to scaling of biophysical and biochemical behaviors may one day help us to formulate a fundamental theory about protein biophysics; which, in turn, may help us to understand fundamental principles of proteins.

This book draws on an eight-year study carried out in the DOCG Prosecco area of Italy, a wine region known worldwide. It is unique in the sense that it is based on one of the most comprehensive investigations into terroir zoning ever performed in Italy.By drawing attention to the complex interrelations between environmental and human factors that influence the growth and production of the Glera grape, the study illustrates the distinct correlation between a wine and its 'terroir'.It shows that the morphology of the sites, the meso and microclimate, the soil, the grapevine planting density, the trellising system, the yield of the vineyard, and the vine water status in the summer lead to unique combinations of grape maturity, acidity, and aroma that ultimately influence the sensory properties of the wines produced. Furthermore, the book details numerous technical and agronomic considerations, specific to the "e;Glera"e; grape variety, for different production strategies, including a section on the impact of climate change on cv "e;Glera"e; phenology."e;The Power of the Terroir: the Case Study of Prosecco Wine"e; represents a valuable resource for anyone involved in studies or research activities in the fields of viticulture, climatology, agronomic sciences or soil sciences, but is also of interest to vine growers, professionals in the wine industry, and wine enthusiasts in general.

Highlighting 15 selected chiral structures, which represent candidate or marketed drugs, and their chemical syntheses, the authors acquaint the reader with the fascinating achievements of synthetic and medicinal chemistry.The book starts with an introduction treating the discovery and development of a new drug entity. Each of the 15 subsequent chapters presents one of the target structures and begins with a description of its biological profile as well as any known molecular mechanisms of action, underlining the importance of its structural and stereochemical features. This section is followed by detailed discussions of synthetic approaches to the chiral target structure, highlighting creative ideas, the scaling-up of laboratory methods and their replacement by efficient modern technologies for large-scale production. Nearly 60 synthetic reactions, most of them stereoselective, catalytic or biocatalytic, as well as chiral separating methodologies are included in the book.Vitomir Sunjic and Michael J. Parnham provide an invaluable source of information for scientists in academia and the pharmaceutical industry who are actively engaged in the interdisciplinary development of new drugs, as well as for advanced students in chemistry and related fields.

This text is based on lectures Couturat gave at the University Caen. It is an outstanding document of the popularization and propagation of symbolic logic around 1900, and it is the only manuscript mentioned in his correspondence that has been rediscovered.

The book deals with continuous piecewise linear differential systems in the plane with three pieces separated by a pair of parallel straight lines. Moreover, these differential systems are symmetric with respect to the origin of coordinates. This class of systems driven by concrete applications is of interest in engineering, in particular in control theory and the design of electric circuits. By studying these particular differential systems we will introduce the basic tools of the qualitative theory of ordinary differential equations, which allow us to describe the global dynamics of these systems including the infinity. The behavior of their solutions, their parametric stability or instability and their bifurcations are described. The book is very appropriate for a first course in the qualitative theory of differential equations or dynamical systems, mainly for engineers, mathematicians, and physicists.