Böcker utgivna av Springer International Publishing AG

This open-access textbook provides an in-depth introduction into the CRISPR-cas9 technology and explores its use across the gamut of biological model systems. As the subject has risen from a significant new discovery to a mainstream molecular biology practice, it is essential that students of molecular biology understand the fundamentals behind CRISPR-Cas9 technology and how it may be employed efficiently and ethically in research.This volume, edited by experts in both, molecular biology and undergraduate education, will teach not only the fundamentals of using CRISPR-Cas9, but also how to successfully employ this technology in classroom settings. The book is written for undergraduates and advanced high school classes in the area of molecular biology, genetics, genomics and biological engineering and will provide a perfect tool for undergraduate lecturers to prepare their classes.

This textbook provides a second course in complex analysis with a focus on geometric aspects. It covers topics such as the spherical geometry of the extended complex plane, the hyperbolic geometry of the Poincaré disk, conformal mappings, the Riemann Mapping Theorem and uniformisation of planar domains, characterisations of simply connected domains, the convergence of Riemann maps in terms of Carathéodory convergence of the image domains, normal families and Picard's theorems on value distribution, as well as the fundamentals of univalent function theory. Throughout the text, the synergy between analysis and geometry is emphasised, with proofs chosen for their directness.The textbook is self-contained, requiring only a first undergraduate course in complex analysis. The minimal topology needed is introduced as necessary. While primarily aimed at upper-level undergraduates, the book also serves as a concise reference for graduates working in complex analysis.

Dominic Ongwen was abducted in 1987 when he was 8 or 9 years old  by the Lord's Resistance Army ('LRA') in Northern Uganda and trafficked as a child soldier; he made multiple unsuccessful attempts to escape, and finally succeeded in late 2014.  He turned himself into the International Criminal Court in 2015 and was prosecuted.  Mr. Ongwen's defence was that he was not responsible for the crimes of the LRA, based on his mental illnesses and duress, stemming from his abduction and subsequent coercion and indoctrination under Joseph Kony within the LRA. In February 2021, the ICC's Trial Chamber IX convicted Dominic Ongwen of 61 charges and two modes of liability and he was sentenced to 25 years incarceration.This work critiques the judicial racial and cultural biases and blindspots in the Ongwen Judgment rendered by the ICC, as related to the affirmative defences of mental disease or defect and duress and to sentencing, from the perspective of the author who served as a defence counsel in the case.BETH S. LYONS is a senior defence counsel, with 30+ years of experience. She has served as a defence counsel at the ICTR and ICC in five international criminal cases.  Previously, she worked for The Legal Aid Society in New York City, in its criminal defence and appeals divisions.

This collection addresses two interrelated questions: How are the lived experiences of contention remembered in the form of auto/biography? How is life writing, as an act of cultural remembrance, used in activism? Building on cutting-edge scholarship on the socio-political potential of narrating lived experience, this volume takes life-writing as a new point of observation on the entanglement between memory and activism.This is an open access book.Duygu Erbil is affiliate researcher at the Institute for Cultural Inquiry (ICON), Utrecht University. She completed her doctoral degree in Comparative Literature at Utrecht University in 2024. Her PhD project analysed the cultural afterlife of Deniz Gezmi¿ and was part of the project Remembering Activism: The Cultural Memory of Protest in Europe (ReAct).Ann Rigney is professor of Comparative Literature at Utrecht University and PI of the Remembering Activism: The Cultural Memory of Protest in Europe (ReAct). She has published widely in the field of cultural memory studies, including most recently The Visual Memory of Protest (edited with Th. Smits, Amsterdam UP, 2023) and Remembering Hope (forthcoming).Clara Vlessing is a lecturer at Utrecht University and a postdoctoral researcher at Radboud University, Nijmegen. She completed her doctoral degree at Utrecht University in 2023. Her PhD analysed the cultural afterlives of three women revolutionaries and was part of the project Remembering Activism: The Cultural Memory of Protest in Europe (ReAct).

The aim of this text is to introduce discrete mathematics to beginning students of mathematics or computer science. It does this by bringing some coherency into the seemingly incongruent subjects that compose discrete math, such as logic, set theory, algebra, and combinatorics. It emphasizes their theoretical foundations and illustrates proofs along the way. The book prepares readers for the analysis of algorithms by discussing asymptotic analysis and a discrete calculus for sums. The book also deduces combinatorial methods from the foundations that are laid out. Unlike other texts on this subject, there is a greater emphasis on foundational material that leads to a better understanding. To further assist the reader in grasping and practicing concepts, roughly 690 exercises are provided at various levels of difficulty. Readers are encouraged to study the examples in the text and solve as many of the exercises as possible.The text is intended for freshman or sophomore undergraduate students in mathematics, computer science, or similar majors. The assumed background is precalculus. The chapter dependency chart included is designed to help students, independent readers, and instructors follow a systematic path for learning and teaching the material, with the option to explore material in later chapters.

The Dermatology Board Exam consists of 200 multiple-choice items and is administered over a four-hour session. In the United States, there are an estimated 9,600 dermatologists and 7,800 dermatology practices. In 2021, there were 541 new dermatologists certified by the American Board of Dermatologists. This Q&A book is the perfect companion book to Dermatology: Illustrated Study Guide and Comprehensive Board Review and allows readers to gauge their knowledge prior to taking the Dermatology Board. This self-assessment Q&A book contains over 400 multiple-choice questions that addresses topics covered on the exam. It offers over twice the number of questions seen in the Dermatology Board Exam. Each question will discuss core issues in dermatology, including, but not limited to, pediatric cases, infectious diseases, dermatologic surgery, pharmacology, drug reactions, dermatopathology and dermoscopy. Questions will also cover basic science and immunology, offering a comprehensive review for dermatologists taking the board exam or recertifying. This book is the perfect companion to Dermatology: Illustrated Study Guide and Comprehensive Board Review and allows readers to self-assess prior to their board exams.

This book presents philosophy as a historical series of answers to two questions: the meaning question (what does it all mean?) and the reality question (what is real rather than illusory?). Presenting philosophy as a historical series of answers to these two questions gives a new view of philosophy. It reveals a coherence between the disparate problems of philosophy which is not apparent when philosophy is approached in a systematic and timeless manner.On the basis of this historical approach, the book argues that philosophy was initially concerned primarily with the nature of reality but changed its focus when science was established as a separate discipline in the 17th century. Philosophy¿s main concern is now the meaning question with a focus on questions of value as discussed in moral and political philosophy and in aesthetics.This book is essential reading for all scholars and researchers in philosophy and especially those interested in the history of philosophy.

Aimed at healthcare students: medical, nursing, and allied professionals, the textbook covers a broad range of topics in Global Health as investigated and summarized by Cardiff University medical students completing a short course in Global Health. Global Health is an increasingly important aspect of the undergraduate medical curriculum but is rarely formally taught at undergraduate level.It focuses upon health in Low- and Middle-Income Countries (LMIC). Chapters include: What is Global Health; changing demographics and disease burden; Humanitarian medicine, Aid; health in conflict; Sexual Reproductive Health; Gender Based Violence; child health; disability; cancer care; palliative care; infectious disease; neglected tropical disease; the climate crisis and sustainable healthcare, amongst others.

This book draws a pathway from metabolic assessment and nutrition support to advances in renal replacement therapy and organ support in critical care, underling the specific clinical aspect and focusing on medical clinical management in critical care. Metabolic alterations in critically ill patients have been studied for many years. Despite everything, the heterogeneity of critically ill patients, the duration and variable severity of the acute phase of the disease and the numerous confounding factors have hindered progress in this field.A cornerstone of metabolic care is nutrition, that is an essential part of the care for critically ill patients, although the optimal feeding strategy for patients in the intensive care unit is still debated and often remains a challenge for the intensive care team in clinical practice. In addition, acute loss of renal function interferes with the metabolism of all macronutrients, responsible for pro-inflammatory, pro-oxidative and hyper-catabolic situations. The physiological and biological modifications related to acute renal failure in critically ill patients, including the current use of continuous renal replacement therapies, have dramatically changed the type and importance of the metabolic and nutrition disturbances observed during treatment of renal failure.This book - addressed to healthcare providers working in intensive care units - aims to provide a comprehensive synthesis and interpretation of the adult critical care nutrition and critical care nephrology literature, with a particular focus on continuing practice gaps and areas with new data, to assist clinicians in making practical, yet evidence-based decisions regarding nutrition management during the different stages of critical illness.

This book is about the role that social media plays in the lives of individuals, societies, economies and polities. It therefore takes in a wide view of the emergent and changing impacts of social media platforms, and social media practices. As a consequence, it examines social media use through various intellectual and scholarly traditions --psychology, sociology, cultural studies, economics, and (national and global) politics ¿ but it is primarily situated in the field of media and communications studies. As such, it frames its analysis of social media impacts using media studies concepts and terminology, and places media texts, forms, industries and agents (producers, audiences and other users) at the centre of each thematic chapter.

Now in its revised and updated fourth edition, this state-of-the-art clinical textbook presents the current diagnosis and management of pediatric endocrine diseases and disorders as seen by practicing endocrinologists and primary care physicians. Seven thematic sections present the latest evidence for the management of growth, hypothalamic, pituitary, adrenal, thyroid, calcium and bone, and reproductive disorders, as well as metabolic syndromes and endocrine emergencies. This fourth edition includes new topics such as conditions of overgrowth, low bone density and its management, endocrine issues related to sexual identity, mineralocorticoid disorders and endocrine hypertension, and endocrine emergencies. All chapters have been expanded to discuss recent advances in the field, and each chapter contains key points, an introductory discussion of the problem, a review of the clinical features that characterize it, the criteria needed to establish a diagnosis, and a comprehensive therapy section delineating the risks and benefits of the best therapeutic options available. Completing each chapter are concluding sections presenting relevant case material and multiple-choice review questions for students, residents and fellows. Pediatric Endocrinology: A Practical Clinical Guide, Fourth Edition is a comprehensive resource for all clinicians concerned with the myriad endocrine disorders seen in children and adolescents.

This textbook provides an undergraduate introduction to Galois theory and its most notable applications.Galois theory was born in the 19th century to study polynomial equations. Both powerful and elegant, this theory was at the origin of a substantial part of modern algebra and has since undergone considerable development. It remains an extremely active research subject and has found numerous applications beyond pure mathematics. In this book, the authors introduce Galois theory from a contemporary point of view. In particular, modern methods such as reduction modulo prime numbers and finite fields are introduced and put to use. Beyond the usual applications of ruler and compass constructions and solvability by radicals, the book also includes topics such as the transcendence of e and ¿, the inverse Galois problem, and infinite Galois theory.Based on courses of the authors at the École Polytechnique, the book is aimed at students with a standard undergraduate background in (mostly linear) algebra. It includes a collection of exam questions in the form of review exercises, with detailed solutions.

This book discusses in detail the pathological aspects associated with alterations in the gut microbiota and the pathogenesis of different disorders related to dysbiosis. The volume describes the impact of dysbiosis on organs other than the gut and brain, such as metabolic diseases, cancer, gynecologic disorders, aging, or pediatric pathologies. Additionally, it associates the mechanisms and metabolic signaling pathways related to gut microbiota homeostasis and alterations with their clinical impact, highlighting the importance of translational research on dysbiosis.The volume is divided into 12 chapters: the first two chapters present diagnostic methods and therapeutic options, including prebiotics and probiotics. The remaining ten chapters specifically focus on diseases of different organs. Moreover, the relevance of these findings to precision medicine will be discussed. The book provides biomedical professionals, basic researchers, and clinical practitioners, especially those specialized in Precision Medicine and Integrative Medicine, with information about the effects of dysbiosis on the physiopathology of various diseases. It also includes updated evidence on the impact of dysbiosis on numerous pathologies, such as metabolic diseases, cancer, gynecologic disorders, aging, or pediatric pathologies, going beyond gastrointestinal and central nervous system diseases typically covered in many publications.Furthermore, the book addresses the translational aspect of dysbiosis. It starts with the basic research knowledge on dysbiosis and disease and aims to provide a translational approach applicable to clinical practice. By combining the fundamental knowledge of biomedical researchers with the clinical applicability of healthcare practitioners, this book bridges the gap between theory and practice.

"This is a very welcome and timely book, which makes a compelling case for a more strategic approach to the development of high-trust employment relations and for engaging constructively with trade unions. Drawing on a wealth of case studies and written in an engaging and accessible style, it will be a superb resource for under-graduate students, those taking CIPD-accredited courses, as well as for managers and trade union representatives."- Chris Rees, Professor of Employment Relations, Royal Holloway, University of London, UKIn an era of rapid technological, economic and political change, there is a growing awareness of the challenges of income inequality, employment insecurity and workplace conflict. In this context, positive relationships between management and trade unions offer an opportunity to negotiate change and create fairer and more productive workplaces. Part of the Palgrave Executive Essentials series, this engaging text is the only dedicated resource for executive learners, professionals and students of human resources and labour relations, providing a strategic management guide to employment relations in the unionised workplace. Combining theory with practical examples and tools, this book is a one-stop-shop for students, instructors and practitioners looking to supplement their understanding of employment relations with hands-on knowledge of this vitally important context. It includes case studies, reflective questions, suggested resources and further reading for additional learning.Debbie Sanders is an employment relations specialist with over 30 years' experience. She has led ER teams, been a union official, researcher, writer and lecturer in this field. Today she runs Make Work Better, an employment relations consultancy, where she delivers an executive education programme for some of the UK's largest unionised organisations, helping to build capability in collective employment relations.Joseph Perry has extensive collective employment relations experience in unionised organisations in transport, law enforcement, utilities and politics. He has led HR and ER functions and has supported organisations in the UK and internationally. Joseph co-delivers the UKs only executive education programme for employment relations with Debbie Sanders. He studied Industrial Relations at    the University of Keele.Richard Saundry is a leading authority on the management of discipline, grievance and workplace conflict. He has held senior posts at the Universities of Westminster, Sheffield, Central Lancashire and Plymouth. His work has been published in a wide range of leading international academic journals and he played a major role in developing the Skilled Managers research programme.

This is a open access book. Ranaviruses, double-stranded DNA viruses (family Iridoviridae) that cause systemic, life-threatening disease in a variety of amphibians, reptiles and fish, have contributed to mass die-offs of both wild and captive populations around the globe. These viruses are emerging and increasingly responsible for population declines of ectothermic vertebrates. Because amphibians, reptiles, and freshwater turtles are suitable hosts and among the most imperiled vertebrate taxa in the world, ranaviruses can have significant impacts on biodiversity and ecosystem function. Additionally, many fish that are raised in aquaculture facilities and traded internationally are suitable hosts; thus, the potential economic impact of ranaviruses is significant. Ranaviruses also serve as a model for understanding viral replication and gene function among large double-stranded DNA viruses, e.g., poxviruses, asfarvirus, and ascoviruses. Lastly, study of the host immune response to ranaviral disease and the identification of viral immune evasion genes that negatively regulate host immune functions provide insight into which specific immune elements are most important in protecting host species against severe disease.The effort to produce a 2nd edition of our earlier work grew out of a recent meeting (1st Global Amphibian and Reptile Disease Conference) held in August 2022. Given the continued research in ranaviruses and ranaviral disease since the first edition, this new book updates the latest information on ranaviruses and provides guidance on how to monitor and manage ranaviruses in cold-blooded vertebrate populations.

This text lays the foundation for understanding the beauty and power of discrete-time models. It covers rich mathematical modeling landscapes, each offering deep insights into the dynamics of biological systems. A harmonious balance is achieved between theoretical principles, mathematical rigor, and practical applications. Illustrative examples, numerical simulations, and empirical case studies are provided to enhance mastery of the subject and facilitate the translation of discrete-time mathematical biology into real-world challenges. Mainly geared to upper undergraduates, the text may also be used in graduate courses focusing on discrete-time modeling. Chapters 1-4 constitute the core of the text. Instructors will find the dependence chart quite useful when designing their particular course. This invaluable resource begins with an exploration of single-species models where frameworks for discrete-time modeling are established. Competition models and Predator-prey interactions are examined next followed by evolutionary models, structured population models, and models of infectious diseases. The consequences of periodic variations, seasonal changes, and cyclic environmental factors on population dynamics and ecological interactions are investigated within the realm of periodically forced biological models.This indispensable resource is structured to support educational settings: A first course in biomathematics, introducing students to the fundamental mathematical techniques essential for biological research. A modeling course with a concentration on developing and analyzing mathematical models that encapsulate biological phenomena. An advanced mathematical biology course that offers an in-depth exploration of complex models and sophisticated mathematical frameworks designed to tackle advanced problems in biology.With its clear exposition and methodical approach, this text educates and inspires students and professionals to apply mathematical biology to real-world situations. While minimal knowledge of calculus is required, the reader should have a solid mathematical background in linear algebra.

Discover the profound, surprising, and instructive tales embedded within the tragic earthquakes and tsunamis of the years 1755, 1906, 1960, 1985, 2004, 2011, and 2023. Uncover the impact these events have had on our understanding of the planet we call home and explore how they shaped the destinies of entire nations.In this book, yoüll delve into the intriguing connection between seismic events and human missions to the Moon and Mars; pondering the warnings they carry for our future. As seismic risks on Earth escalate and humanity extends its reach into space, these challenges become pivotal for both current and future seismologists.Lastly, this book will allow you to embark on a riveting journey through the seismic tapestry of our past, present, and the uncharted territories of our future.

This textbook gives an insight into the importance of cell migration in health during development, wound healing and immune responses as well as in disease with particular focus on cancer. The reader will learn about the different ways cells migrate to allow cellular changes during development to occur, as well as responses to injury and threat by foreign invaders. Cell migration is a driver of invasion and ultimately metastasis in cancer and as such we will give examples from highly aggressive cancer such as brain tumours. The book also includes an introduction to mathematical modelling to predict cell migration, information on the development of software for analysis of data generated in 2D and 3D as well as recent developments in the investigations into cell migration using 3D bioprinting.This textbook will be a great learning tool for advanced undergraduate students and Master students with the relevant science degrees such as in cell biology, developmental biology, cancer research, and tumour biology.

Embark on a journey through the rapidly evolving landscape of Marketing Technology (MarTech) with this comprehensive guide. From understanding the strategic imperatives driving MarTech adoption to navigating the intricacies of data-driven customer interaction, this book provides invaluable insights and practical strategies. Explore topics ranging from budget allocation and market potential to data readiness and GDPR compliance, gaining a deep understanding of key concepts and best practices. Whether you're grappling with the complexities of AI integration or seeking to optimize measurement and KPIs, this book equips you with the knowledge and tools needed to thrive in today's digital marketing environment. With decades of industry experience, Ralf Strauss offers in this book a roadmap for success, empowering marketers to navigate the challenges and seize the opportunities presented by MarTech innovation.

This handy and practical book assists emergency doctors in their daily practice offering a quick reference tool to properly diagnose and manage traumatic musculoskeletal lesions.In the opening part it provides readers with basic traumatology knowledge, enabling them to have a constructive discussion with the specialist. The other sections are devoted to upper limbs, lower limbs, pediatric trauma and skull and spine trauma. Following this anatomical subdivision, the authors offer practical tips to recognize hidden injuries, minimize diagnostic errors and avoid common pitfalls. Readers will learn how to combine careful questioning with a thorough clinical examination, backed up by appropriate, high-quality complementary tests. With its handy and easy-to-read format this book is an invaluable tool for emergency doctors and orthopedic residents alike.

This book is focused on modeling with linear differential equations with constant coefficients. The author starts with the elementary natural growth equation and ends with the heat equation on the real line. The emphasis is on linear algebra, Fourier theory, and specifically data analysis, which is given a very prominent role and is often the book's main driving force. All aspects of modeling with linear differential equations are illustrated by analyzing real and simulated data in MATLAB®. These modeling case studies are of particular interest to students who anticipate having to use differential equations in their fields. The book is self-contained and is appropriate as a supplement for a first course in differential equations whose prerequisites include proficiency in multivariate calculus and MATLAB literacy.

The aim of this book is to quickly elevate students to a proficiency level where they can solve linear and nonlinear partial differential equations using state-of-the-art numerical methods. It covers numerous topics typically absent in introductory texts on ODEs and PDEs, including: Computing solutions to chaotic dynamical systems with TRBDF2 Simulating the nonlinear diffusion equation with TRBDF2 Applying Newton¿s method and GMRES to the nonlinear Laplace equation Analyzing gas dynamics with WENO3 (1D Riemann problems and 2D supersonic jets) Modeling the drift-diffusion equations with TRBDF2 and PCG Solving the classical hydrodynamic model (electro-gas dynamics) with WENO3 and TRBDF2The book features 34 original MATLAB programs illustrating each numerical method and includes 93 problems that confirm results discussed in the text and explore new directions. Additionally, it suggests eight semester-long projects. This comprehensive text can serve as the basis for a one-semester graduate course on the numerical solution of partial differential equations, or, with some advanced material omitted, for a one-semester junior/senior or graduate course on the numerical solution of ordinary and partial differential equations. The topics and programs will be of interest to applied mathematicians, engineers, physicists, biologists, chemists, and more.

Economic history interprets crises as cyclical events. However, we are currently experiencing an acceleration of these cycles. In 25 years (2000-2024), we have lived the Twin Towers Attack in 2001, the Financial Crash in 2008, the Covid-2019 pandemic, and current military crises in Ukraine and the Middle East.In the first edition of this book, the authors identified three decision-making patterns (short termism, centralization, and parochialism) characterizing Boardrooms decisions during the financial crash. In this revised and updated edition, the authors explore the main commonalities and differences of decision-making processes between the previous financial crisis and the current continuous crisis regime. The authors highlight how and where the organizational impact of short-termism, centralization and parochialism on Boards decision-making can prove detrimental.Alberto Lavín is Strategy Adjunct Professor for IE Business School. Previously a partner with Accenture, the consulting giant, he now heads his own consulting practice and acts as a family business nonexecutive director and advisor. In 2014, he published, together with Carmelo Mazza, "Boards under crisis: board action under pressure".Carmelo Mazza holds a PhD in Business Economics from IESE Business School. His research interests focus on decision-making and on creative processes. In the last three decades, he has taught in leading institutions (among others, Copenhagen Business School, University of Rome "La Sapienza", and IE Business School) and acted as management consultant and top manager.