Neuroinflammatory Mechanisms in Alzheimer's Disease Basic and Clinical Research

Basic Research Overview.- Cellular and molecular mechanisms of Alzheimer's disease inflammation.- Clinical Research Overview.- Anti-inflammatory agents as possible protective factors for Alzheimer's disease: Analysis of relevant epidemiological studies.- Topics of Special Interest.- Role and regulation of early complement activation products in Alzheimer's disease.- Complement mediator systems in Alzheimer's disease.- Amyloid ? peptide interactions with the classical pathway of complement.- Physiology and biochemistry of the interleukin-6 receptor complex. Implications for CNS disorders and Alzheimer's disease.- Interactions of ?2-macroglobulin and amyloid ? peptide.- Proinflammatory actions of derivatives of the ? amyloid precursor protein.- The involvement of glial cell-derived reactive oxygen and nitrogen species in Alzheimer's disease.- The role of cyclooxygenase in Alzheimer's disease neurodegeneration.- Microglia.- Neurons.- The gero-inflammatory manifold.