Böcker i SpringerBriefs in Molecular Science-serien

This brief offers an introduction to the fascinating new field of quantitative read-across structure-activity relationships (q-RASAR) as a cheminformatics modeling approach in the background of quantitative structure-activity relationships (QSAR) and read-across (RA) as data gap-filling methods. It discusses the genesis and model development of q-RASAR models demonstrating practical examples. It also showcases successful case studies on the application of q-RASAR modeling in medicinal chemistry, predictive toxicology, and materials sciences. The book also includes the tools used for q-RASAR model development for new users. It is a valuable resource for researchers and students interested in grasping the development algorithm of q-RASAR models and their application within specific research domains.

This brief is a concise guide that explores the theory and practical aspects of improving enantioselectivity in enzymatic kinetic resolution, with a specific focus on the role of hydrolases in this process. Enzymatic kinetic resolution is a valuable technique for obtaining enantiopure compounds, and hydrolases are highlighted as a crucial class of enzymes widely used in industries for chiral synthesis involving kinetic resolution. The book emphasizes the importance of tuning and optimizing the enzymatic kinetic resolution process to achieve the highest possible enantiomeric excess in the final product or starting material while maintaining the desired yield. Through illustrative examples, the text aims to make the concept accessible and appealing to graduate students, researchers, and young organic chemists seeking to incorporate hydrolases in their stereoselective synthesis endeavors.

This book covers the design and development of glucocorticoid receptor modulators (GRM) from cortisol to antibody-drug conjugate payloads over the last 70 years. The author starts with an introduction to the background of glucocorticoid receptor modulators as potential therapeutic modalities. This is followed by seven chapters in which he collates and discusses the medicinal chemistry journey of GRMs, reviewing topics such as cortisol-based glucocorticoids, the different approaches that have been pursued to enable chronic dosing of GRM compounds by inactivation in plasma and the liver, the application of prodrugs to GRMs, selective GRMs, targeted delivery of GRMs using polymers and nanoparticles, and rational drug design approaches applied in the development of GRMs. Particular attention is given to the development of glucocorticoid receptor modulators as immunology antibody-drug conjugate payloads. In the book¿s final chapter, the author critiques the medicinal chemistry progress madesince the discovery of cortisone and the promise of the latest antibody-drug conjugates that release a GRM payload. In this book, readers will also find an overview of the X-ray structures of glucocorticoid receptor antagonists and a list of all the earlier reviews that cover part of the medicinal chemistry story of GRM collated by keywords organized in a table. With several examples of crystal structures and molecular modeling, this book illustrates the huge effort by multiple companies and research groups to develop glucocorticoid receptor modulators. Professionals and scholars alike will find it a handy tool, and appreciate the latest research findings that it presents.

This book summarizes the progress made to functional immobilize G protein-coupled receptors (GPCRs) through site-specific or orientated recognition in both non-covalent and covalent manners. The last decade is the dawn of the ¿post-structural biology¿ era for G protein-coupled receptor research. As an emerging approach for state-of-the-art immobilization, this book discusses efforts to explore the elegance of naturally-occurring biochemical reactions by using their high specificity and robust reactivity in the complex system, such as site-specific conjugation by covalent recognition between enzymes and their substrates. With the perspective of protein-drug interactions, this book also reviews the applications of protein immobilization, with an emphasis on G protein-coupled receptors, in drug discovery and protein-ligand interaction analysis. In addition, the merits, opportunities and disadvantages are analyzed for different immobilization methods, and a perspective for future directions is presented. Given its scope, this book appeals to a broad readership, particularly researchers engaged in the field of analytical chemistry, bioconjugate chemistry, and chemical biology, and other related field, as well as teachers of relevant majors in colleges and universities.

This book provides a comprehensive insight into the current research trends and ongoing advances in biomedical applications of magnetic nanoparticles. New uses for magnetic nanoparticles in biomedical fields such as magnetic particle imaging, microfluidics applications, organelle isolation, nanovaccines, and magnetogenetics are presented in keeping with traditional applications of magnetic nanoparticles in clinical diagnostics and therapeutics. Each section of the book provides feature questions with answers available from various research showcases and literature references, together with numerous illustrations to help readers grasp key ideas. The book was written for graduate students and researchers in the fields of magnetic nanomedicine and nanobiotechnology. 

This book constructs a history of Newtown Creek's industrial expansion during the period that began in the 1840s and continued through the early years of the 20th century. In that period, the production of reagent chemicals and refined materials near the center of modern-day New York City grew steadily, as practitioners, alert to European advances in chemical science, developed and applied increasingly sophisticated technologies. Innovations in methods of production, ready access to domestic and international markets, and sustained growth in volumes of production at Newtown Creek in the late 19th century had profound consequences for the practice of industrial chemistry in the United States and for the economic vitality of the City of New York. Industrial practice progressed from the recovery of animal tissues to the refining of crude petroleum and the production of high-purity copper and other metals from mineral ores. With attention to each company's technical expertise and principal products, this book examines the interdependence of the chemicals- and materials-producing industries that thrived along Newtown Creek's shores. The author recounts Newtown Creek's industrial history alongside the stories of well-known New Yorkers - Peter Cooper, Charles Pratt, John D. and William Rockefeller - and other less celebrated or less notorious characters.This book provides a valuable account of New York's history in the manufacture of reagent chemicals and refined fuels and metals and will appeal to researchers, scholars and historians interested in the early years of industrial chemistry.

This brief outlines the state-of-art of the food industry within the Indian Sub-continent, providing a detailed insight into the current science of nutrition and industrial technology.The Hygiene, Integrity, Traceability and Sharing (HITS) strategy has been proposed recently as a coordinated and powerful tool to contextualize the plethora of different menaces for the food consumer. The book examines this approach from eight different perspectives, with a particular emphasis on the Indian Subcontinent. Topics such as food additives, the importance of water in the food industry, the use of antioxidants, and novel food preservation methods are used to illustrate these points of view.This book is particularly appealing as a guide for graduate and undergraduate courses covering food production, food safety, and the training of teachers working in these science areas. 

This book addresses the impact of soil and water quality on food production, and explores soil and water conservation measures to be applied at farm level for agricultural sustainability. Divided into 8 chapters, the book covers topics such as soil properties responsible for soil loss, the impact of climate change, water and biological factors on soil chemistry, the effect of soil on the quality of water including sustaining aquaculture productivity and environment of wetlands, soil and water qualities necessary for irrigation, management of soil organic carbon, and the importance of soil moisture conservation including agroforestry for food production. Particular attention is given to the management of soil organic carbon in sustainable crop cultivation as well as reducing soil erosion and nutrient loss from soil from cultivated lands. The book concludes with a chapter that integrates soil and water conservation with sustainable food production and food safety.

Furthermore, the dramatic problem of plastic waste accumulation and the conservation of oil and food resources need to be taken into consideration.This book presents eco-friendly packaging strategies to reduce food and plastic waste and address the end-of-life issues of persistent materials.

This book explores the role that some natural molecules found in fruits and vegetables, and their derivatives, play in excessive oxidation reactions that lead to inflammation in the human body.

This book introduces vibronic coupling density and vibronic coupling constant analyses as a way to understand molecular structure and chemical reactions.

This book presents a new view of the mechanism of functional expression of ATP-driven motors (proteins or protein complexes).

This book offers a comprehensive overview of recent theoretical studies on rhodium-catalyzed C-H functionalization, a topic that has attracted considerable attention over the years.

This book traces the global chemical history of cannabidiol (CBD), which is a compound that originates partially from hemp (the fiber), marijuana (the popularized term for medicinal/recreational use), and cannabis (the species sativa).

This book addresses the traditional use of a specific crop legume, grass pea (Lathyrus sativus), as a food product and ingredient for typical food products.

This book reviews the authenticity of certain Street Food specialties from the viewpoint of food chemists.

This book focuses on polyphenols in the Mediterranean diet, providing a detailed overview of their chemical structure, extraction and analysis methods, and their role in the diet and in flavor.Phenols are important not only in terms of preventing a number of diseases due to their antimicrobial and antioxidant effects, but also in shaping our perception of foods. The first chapter discusses consumersΓÇÖ sensory assessment of foods containing polyphenols in terms of flavor and color, as well as the chemical properties and natural sources of phenolic compounds. The second chapter examines hygiene and safety claims with respect to naturally occurring polyphenols, especially in connection with organoleptic features. The third and final chapter examines the dietary sources of these molecules from various fruits, including processed products such as infusions, wines, oils and olives. Given its scope, this book is a valuable resource for researchers in academia and industry interested in food safety, hygiene and production issues related to the Mediterranean diet.

This book explores the lively chemistry culture that arose during the 17th century in Colonial New England.

Chemicals in the Food and Beverage Industry.- Uses of Chemicals in the Food and Beverage Industry.- The Durable Management of Chemicals in the Food Industry and Annexed Laboratories.- The Future of Chemicals in the Food Production Ambit.

This book focuses on the use of food gases in the food industry, their different applications and their role in food processing, packaging and transportation.

This book discusses a major issue in the food contact materials industry: non-intentionally added substances (NIAS), and their impact on PET-bottled water.

Historically, the reaction was used in chemical analysis and to highlight the nature of chemical reactions, the laws of chemistry, models and theories of chemistry, chemical nomenclature, mathematics and data analysis, and instrumentation, which are important ingredients of what one might call the nature of chemistry.

This book focuses on both production and extraction aspects of Polyhydroxyalkanoates (PHAs) for their commercialization purpose.

This book presents the concept of food sharing from a European perspective, and provides a concise analysis of its safety implications and the chemical properties of recovered foods. In our modern world, 33% of the total food produced is lost each year, with serious economic, environmental and social consequences.

This book provides an introduction to the fundamental and applied aspects of sonochemistry, discussing a number of basic concepts in sonochemistry, such as how ultrasonic waves interact with gas bubbles in liquids to generate cavitation, and how the high temperatures generated within cavitation bubbles could be estimated.

This book explains the role of food-oriented (or 'food-centric') quality system standards in the modern food and beverage industry. It discusses food safety schemes based on the international norm ISO 9001 and the "Hazard Analysis and Critical Control Points" approach, and also introduces the new Global Standard for Food Safety (GSFS) and the International Featured Standard (IFS, 7th ed.), outlining standardization for international equivalence (while maintaining the necessary flexibility and independence - which is not always easy an easy task).Providing selected specific examples, it examines the problems of chemical additives and possible cross-contaminations between different production lines, as well as adequate reactions to and handling of intentional adulterations. In addition, it includes a chapter focusing on quality audits and technical data sheets in the food industry, and a final chapter describing the certification of food-grade lubricants in the food industry, especially with regard to allergenic substances.

Chapter two addresses the role of carbohydrates in inexpensive and tasty foods, while chapter three outlines how vegetable fats, notably palm oil, are used in selected industrial foods and explores their relation to hyper-palatability and other health issues.

This book describes the consequences of an increased demand for food for human consumption for the global food industry. Chapter two discusses how the expansion of cropland and pastures to meet the rising demand for food is damaging the environment, while chapter three examines the impact of bee viruses on food crops and production.

It starts with the dynamics of a single bubble under ultrasound, and then addresses few-bubble systems and the formation and development of bubble structures, before briefly reviewing work on isolated bubbles in standing acoustic waves (bubble traps) and multibubble systems where translation and interaction of bubbles play a major role.